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Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results.
Krasilnikova, Olga; Yakimova, Anna; Ivanov, Sergey; Atiakshin, Dmitri; Kostin, Andrey A; Sosin, Dmitry; Shegay, Peter; Kaprin, Andrey D; Klabukov, Ilya.
Afiliación
  • Krasilnikova O; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, Russia.
  • Yakimova A; A. Tsyb Medical Radiological Research Centre-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Zhukov St. 10, 249031 Obninsk, Russia.
  • Ivanov S; A. Tsyb Medical Radiological Research Centre-Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Zhukov St. 10, 249031 Obninsk, Russia.
  • Atiakshin D; Department of Urology and Operative Nephrology, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklay St. 6, 117198 Moscow, Russia.
  • Kostin AA; Scientific and Educational Resource Center for Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
  • Sosin D; Department of Urology and Operative Nephrology, Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklay St. 6, 117198 Moscow, Russia.
  • Shegay P; Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency, 119121 Moscow, Russia.
  • Kaprin AD; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, Russia.
  • Klabukov I; National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Koroleva St. 4, 249036 Obninsk, Russia.
Int J Mol Sci ; 24(22)2023 Nov 13.
Article en En | MEDLINE | ID: mdl-38003439
Treatment of a wide variety of defects in the oral and maxillofacial regions requires the use of innovative approaches to achieve best outcomes. One of the promising directions is the use of gene-activated materials (GAMs) that represent a combination of tissue engineering and gene therapy. This approach implies that biocompatible materials will be enriched with gene-carrying vectors and implanted into the defect site resulting in transfection of the recipient's cells and secretion of encoded therapeutic protein in situ. GAMs may be presented in various designs depending on the type of material, encoded protein, vector, and way of connecting the vector and the material. Thus, it is possible to choose the most suitable GAM design for the treatment of a particular pathology. The use of plasmids for delivery of therapeutic genes is of particular interest. In the present review, we aimed to delineate the principle of work and various designs of plasmid-based GAMs and to highlight results of experimental and clinical studies devoted to the treatment of periodontitis, jaw bone defects, teeth avulsion, and other pathologies in the oral and maxillofacial regions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Ingeniería de Tejidos Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Ingeniería de Tejidos Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza