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Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia.
Harikumar, Amritha; Solovyeva, Kseniya P; Misiura, Maria; Iraji, Armin; Plis, Sergey M; Pearlson, Godfrey D; Turner, Jessica A; Calhoun, Vince D.
Afiliación
  • Harikumar A; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
  • Solovyeva KP; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
  • Misiura M; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
  • Iraji A; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
  • Plis SM; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
  • Pearlson GD; Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
  • Turner JA; The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Calhoun VD; The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA. vcalhoun@gsu.edu.
Curr Neurol Neurosci Rep ; 23(12): 937-946, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37999830
PURPOSE OF REVIEW: Over the last decade, evidence suggests that a combination of behavioral and neuroimaging findings can help illuminate changes in functional dysconnectivity in schizophrenia. We review the recent connectivity literature considering several vital models, considering connectivity findings, and relationships with clinical symptoms. We reviewed resting state fMRI studies from 2017 to 2023. We summarized the role of two sets of brain networks (cerebello-thalamo-cortical (CTCC) and the triple network set) across three hypothesized models of schizophrenia etiology (neurodevelopmental, vulnerability-stress, and neurotransmitter hypotheses). RECENT FINDINGS: The neurotransmitter and neurodevelopmental models best explained CTCC-subcortical dysfunction, which was consistently connected to symptom severity and motor symptoms. Triple network dysconnectivity was linked to deficits in executive functioning, and the salience network (SN)-default mode network dysconnectivity was tied to disordered thought and attentional deficits. This paper links behavioral symptoms of schizophrenia (symptom severity, motor, executive functioning, and attentional deficits) to various hypothesized mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia Límite: Humans Idioma: En Revista: Curr Neurol Neurosci Rep Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia Límite: Humans Idioma: En Revista: Curr Neurol Neurosci Rep Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos