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Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure.
Zhang, Guangbo; Yang, Guochun; Zhou, Yanzhao; Cao, Zhengtao; Yin, Ming; Ma, Lin; Fan, Ming; Zhao, Yong-Qi; Zhu, Lingling.
Afiliación
  • Zhang G; Department of Cognition Sciences and Stress Medicine, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing, China.
  • Yang G; Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
  • Zhou Y; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
  • Cao Z; Department of Cognition Sciences and Stress Medicine, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing, China.
  • Yin M; Air Force Medical Center, PLA, Beijing, China.
  • Ma L; The First Medical Center of Chinese, PLA General Hospital, Beijing, China.
  • Fan M; The First Medical Center of Chinese, PLA General Hospital, Beijing, China.
  • Zhao YQ; Department of Cognition Sciences and Stress Medicine, Beijing Institute of Basic Medical Sciences, No. 27 Taiping Road, Haidian District, Beijing, China.
  • Zhu L; Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
Pflugers Arch ; 476(2): 197-210, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37994929
Intermittent hypoxia training (IHT) is a promising approach that has been used to induce acclimatization to hypoxia and subsequently lower the risk of developing acute mountain sickness (AMS). However, the effects of IHT on cognitive and cerebrovascular function after acute hypoxia exposure have not been characterized. In the present study, we first confirmed that the simplified IHT paradigm was effective at relieving AMS at 4300 m. Second, we found that IHT improved participants' cognitive and neural alterations when they were exposed to hypoxia. Specifically, impaired working memory performance, decreased conflict control function, impaired cognitive control, and aggravated mental fatigue induced by acute hypoxia exposure were significantly alleviated in the IHT group. Furthermore, a reversal of brain swelling induced by acute hypoxia exposure was visualized in the IHT group using magnetic resonance imaging. An increase in cerebral blood flow (CBF) was observed in multiple brain regions of the IHT group after hypoxia exposure as compared with the control group. Based on these findings, the simplified IHT paradigm might facilitate hypoxia acclimatization, alleviate AMS symptoms, and increase CBF in multiple brain regions, thus ameliorating brain swelling and cognitive dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Mal de Altura / Disfunción Cognitiva Límite: Humans Idioma: En Revista: Pflugers Arch Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Encefálico / Mal de Altura / Disfunción Cognitiva Límite: Humans Idioma: En Revista: Pflugers Arch Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania