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Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF.
Cermakova, Katerina; Tao, Ling; Dejmek, Milan; Sala, Michal; Montierth, Matthew D; Chan, Yuen San; Patel, Ivanshi; Chambers, Courtney; Loeza Cabrera, Mario; Hoffman, Dane; Parchem, Ronald J; Wang, Wenyi; Nencka, Radim; Barbieri, Eveline; Hodges, H Courtney.
Afiliación
  • Cermakova K; Department of Molecular and Cellular Biology, and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
  • Tao L; Department of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer and Hematology Center, Baylor College of Medicine, Houston, TX, USA.
  • Dejmek M; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
  • Sala M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Montierth MD; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Chan YS; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Patel I; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.
  • Chambers C; Department of Molecular and Cellular Biology, and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
  • Loeza Cabrera M; Stem Cells and Regenerative Medicine Center, Center for Cell and Gene Therapy, and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Hoffman D; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
  • Parchem RJ; Department of Molecular and Cellular Biology, and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
  • Wang W; Translational Biology and Molecular Medicine Graduate Program, Houston, TX, USA.
  • Nencka R; Department of Molecular and Cellular Biology, and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
  • Barbieri E; Development, Disease Models and Therapeutics Graduate Program, Baylor College of Medicine, Houston, TX, USA.
  • Hodges HC; Department of Molecular and Cellular Biology, and Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA.
Nucleic Acids Res ; 52(1): 4-21, 2024 Jan 11.
Article en En | MEDLINE | ID: mdl-37993417
Cancer cells driven by runaway transcription factor networks frequently depend on the cellular machinery that promotes DNA accessibility. For this reason, recently developed small molecules that impair SWI/SNF (or BAF) chromatin remodeling activity have been under active evaluation as anti-cancer agents. However, exactly when SWI/SNF activity is essential in dependent cancers has remained unknown. By combining live-cell imaging and genome-wide profiling in neuroblastoma cells, Cermakova et al. discover that SWI/SNF activity is needed for survival only during G1 phase of the cell cycle. The authors reveal that in several cancer settings, dependency on SWI/SNF arises from the need to reactivate factors involved in G1-S transition. Because of this role, authors find that SWI/SNF inhibition potentiates cell-cycle exit by retinoic acid.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Fase G1 / Neoplasias Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Fase G1 / Neoplasias Límite: Humans Idioma: En Revista: Nucleic Acids Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido