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Mass Spectrometry-Based Multiomics Identifies Metabolic Signatures of Sarcopenia in Rhesus Monkey Skeletal Muscle.
Pergande, Melissa R; Osterbauer, Katie J; Buck, Kevin M; Roberts, David S; Wood, Nina N; Balasubramanian, Priya; Mann, Morgan W; Rossler, Kalina J; Diffee, Gary M; Colman, Ricki J; Anderson, Rozalyn M; Ge, Ying.
Afiliación
  • Pergande MR; Department of Cell and Regenerative Biology, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Osterbauer KJ; Department of Medicine, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Buck KM; Department of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.
  • Roberts DS; Department of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.
  • Wood NN; Department of Medicine, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Balasubramanian P; Department of Medicine, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Mann MW; Department of Medicine, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Rossler KJ; Department of Cell and Regenerative Biology, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Diffee GM; Department of Kinesiology, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.
  • Colman RJ; Department of Cell and Regenerative Biology, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
  • Anderson RM; Wisconsin National Primate Research Center, University of Wisconsin─Madison, Madison, Wisconsin 53715, United States.
  • Ge Y; Department of Medicine, University of Wisconsin─Madison, Madison, Wisconsin 53705, United States.
J Proteome Res ; 2023 Nov 22.
Article en En | MEDLINE | ID: mdl-37991985
Sarcopenia is a progressive disorder characterized by age-related loss of skeletal muscle mass and function. Although significant progress has been made over the years to identify the molecular determinants of sarcopenia, the precise mechanisms underlying the age-related loss of contractile function remains unclear. Advances in "omics" technologies, including mass spectrometry-based proteomic and metabolomic analyses, offer great opportunities to better understand sarcopenia. Herein, we performed mass spectrometry-based analyses of the vastus lateralis from young, middle-aged, and older rhesus monkeys to identify molecular signatures of sarcopenia. In our proteomic analysis, we identified proteins that change with age, including those involved in adenosine triphosphate and adenosine monophosphate metabolism as well as fatty acid beta oxidation. In our untargeted metabolomic analysis, we identified metabolites that changed with age largely related to energy metabolism including fatty acid beta oxidation. Pathway analysis of age-responsive proteins and metabolites revealed changes in muscle structure and contraction as well as lipid, carbohydrate, and purine metabolism. Together, this study discovers new metabolic signatures and offers new insights into the molecular mechanisms underlying sarcopenia for the evaluation and monitoring of a therapeutic treatment of sarcopenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Proteome Res Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Proteome Res Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos