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Assessment of quality of life in patients with craniopharyngioma and identification of risk factors for compromised overall wellness.
Lin, Ben; Xiang, Shiyuan; Chen, Jiajun; Jing, Yu; Ye, Zhao; Zhang, Yichao; Cao, Xiaoyun; Yin, Zhiwen; Qiao, Nidan; Zhou, Xiang.
Afiliación
  • Lin B; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
  • Xiang S; National Center for Neurological Disorders, Shanghai, China.
  • Chen J; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China.
  • Jing Y; Neurosurgical Institute of Fudan University, Shanghai, China.
  • Ye Z; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China.
  • Zhang Y; These authors contributed equally to this work.
  • Cao X; Department of Nursery, Huashan Hospital West Campus, Shanghai, China.
  • Yin Z; These authors contributed equally to this work.
  • Qiao N; Department of Nursery, Huashan Hospital West Campus, Shanghai, China.
  • Zhou X; These authors contributed equally to this work.
Arch Endocrinol Metab ; 68: e230001, 2023 Nov 17.
Article en En | MEDLINE | ID: mdl-37988666
Objective: Quality of Life (QoL) has been a multifactorial concerning issue in oncology. We aimed to inspect the pre-operative QoL among patients with craniopharyngioma and to explore the potential correlations between parameters of QoL and clinical indices. Subjects and methods: We enrolled a total of 109 patients with craniopharyngioma. We utilized Short Form 36 (SF-36), Symptom Check List-90, Generalized Anxiety Disorder Questionnaire scale (GAD7), Patient Health Questionnaire Depression (PHQ9) and Pittsburgh Sleep Quality Index to prospectively evaluated their QoL. Parameters of QoL along with clinical indices were compared among sub-groups divided according to Puget classification. Correlation analyses and regression analyses were performed to detect influential determinants to self-reported wellness. Results: Patients presented impaired QoL compared with general population (p < 0.001), as assessed by SF-36. Correlation analyses indicated the detrimental influence resulting from central diabetes insipidus (CDI). Multivariate linear regression unveiled the adverse effect of CDI on Mental Component Summary (coefficient = -13.869, p= 0.007), GAD7 total score (coefficient = 2.072, p = 0.049) as well as PHQ9 total score (coefficient = 3.721, p = 0.001). Multivariate logistic regression verified CDI as a risk factor of developing depressive symptoms (OR = 6.160, p = 0.001). Conclusion: QoL of patients with craniopharyngioma was remarkably compromised before operation. CDI exerted detrimental influences on patients' QoL and it might serve as a marker for early identification of patients at risk of depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Craneofaringioma / Diabetes Insípida Neurogénica Límite: Humans Idioma: En Revista: Arch Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Craneofaringioma / Diabetes Insípida Neurogénica Límite: Humans Idioma: En Revista: Arch Endocrinol Metab Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil