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Slower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia.
Kikuchi, Yuki; Yada, Yuji; Otsuka, Yuji; Ito, Fumiaki; Tanifuji, Hiroaki; Komatsu, Hiroshi; Tomita, Hiroaki.
Afiliación
  • Kikuchi Y; Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. ykikuchi@sand.ocn.ne.jp.
  • Yada Y; Department of Psychiatry, Kodama Hospital, Ishinomaki, Miyagi, Japan. ykikuchi@sand.ocn.ne.jp.
  • Otsuka Y; Department of Psychiatry, Okayama Psychiatric Medical Center, Okayama, Japan.
  • Ito F; Department of Psychiatry, Asahi General Hospital, Asahi, Japan.
  • Tanifuji H; National Hospital Organization Hanamaki Hospital, Hanamaki, Japan.
  • Komatsu H; Department of Pharmacy, Kodama Hospital, Ishinomaki, Miyagi, Japan.
  • Tomita H; Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan.
Schizophrenia (Heidelb) ; 9(1): 82, 2023 Nov 20.
Article en En | MEDLINE | ID: mdl-37985654
Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson's product-moment correlation indicated a significant delay in the fever onset date with slower titration. Most fever onset cases occurred within 4 weeks, even with slow titration. Therefore, clinicians should remain vigilant in monitoring clozapine-induced fever within 4 weeks of clozapine initiation, regardless of the titration rate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Schizophrenia (Heidelb) Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Schizophrenia (Heidelb) Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania