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Antiviral activity of SP81 peptide against Enterovirus A71 (EV-A71).
Abd-Aziz, Noraini; Lee, Michelle Felicia; Ong, Seng-Kai; Poh, Chit Laa.
Afiliación
  • Abd-Aziz N; Centre for Virus and Vaccine Research (CVVR), School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
  • Lee MF; Centre for Virus and Vaccine Research (CVVR), School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
  • Ong SK; Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia.
  • Poh CL; Centre for Virus and Vaccine Research (CVVR), School of Medical and Life Sciences, Sunway University, 47500, Subang Jaya, Selangor, Malaysia. Electronic address: chitlaa.poh@gmail.com.
Virology ; 589: 109941, 2024 01.
Article en En | MEDLINE | ID: mdl-37984152
ABSTRACT
The hand, food, and mouth disease (HFMD) is primarily caused by Enterovirus A71 (EV-A71). EV-A71 outbreaks in the Asia Pacific have been associated with severe neurological disease and high fatalities. Currently, there are no FDA-approved antivirals for the treatment of EV-A71 infections. In this study, the SP81 peptide, derived from the VP1 capsid protein of EV-A71 was shown to be a promising antiviral candidate for the treatment of EV-A71 infections. SP81 peptide was non-toxic to RD cells up to 45 µM, with a half-maximal cytotoxic concentration (CC50) of 90.32 µM. SP81 peptide exerted antiviral effects during the pre- and post-infection stages with 50% inhibitory concentrations (IC50) of 4.529 µM and 1.192 µM, respectively. Direct virus inactivation of EV-A71 by the SP81 peptide was also observed with an IC50 of 8.076 µM. Additionally, the SP81 peptide exhibited direct virus inactivation of EV-A71 at 95% upon the addition of the SP81 peptide within 5 min. This study showed that the SP81 peptide exhibited significant inhibition of EV-A71 and could serve as a promising antiviral agent for further clinical development against EV-A71 infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterovirus / Enterovirus Humano A / Infecciones por Enterovirus / Enfermedad de Boca, Mano y Pie Límite: Humans Idioma: En Revista: Virology Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enterovirus / Enterovirus Humano A / Infecciones por Enterovirus / Enfermedad de Boca, Mano y Pie Límite: Humans Idioma: En Revista: Virology Año: 2024 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Estados Unidos