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The effect of topical magnesium on healing of pre-clinical burn wounds.
Rahmanian, Elham; Tanideh, Nader; Karbalay-Doust, Saied; Mehrabani, Davood; Rezazadeh, Davood; Ketabchi, Deniz; EskandariRoozbahani, Narges; Hamidizadeh, Nasrin; Rahmanian, Farzad; Namazi, Mohammad Reza.
Afiliación
  • Rahmanian E; Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, And Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Tanideh N; Stem cells technology research center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Karbalay-Doust S; Histomorphometry and Stereology research Center, Shiraz University of Medical Sciences, Shiraz, iran.
  • Mehrabani D; Stem Cell Technology Research Center, Shiraz, Iran. and Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB, Canada.
  • Rezazadeh D; Molecular Medicine Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ketabchi D; Haj Daei Clinic, Kermanshah University of Medical Science, Kermanshah, Iran.
  • EskandariRoozbahani N; Clinical research development center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Hamidizadeh N; Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Rahmanian F; Paramedic of Jahrom University of Medical Sciences, Jahrom, Iran.
  • Namazi MR; Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: namazi_mr@yahoo.com.
Burns ; 50(3): 630-640, 2024 Apr.
Article en En | MEDLINE | ID: mdl-37980271
BACKGROUND: Magnesium (Mg) is an essential factor in the healing process. This study aimed to evaluate the effect of Mg creams on healing burn wounds in the rat model. METHODS: To induce burns under general anaesthesia, a 2 × 2 cm2, 100 °C plate was placed for 12 s between the scapulas in 100 male adult Sprague Dawley rats. Animals were divided into five groups (n = 20); positive control (induced burn without treatment); vehicle control (received daily Eucerin cream base topically); comparative control (induced burn and treated daily with Alpha burn cream topically); Treatment 1 and 2 (received daily Mg cream 2% and 4% topically, respectively). All animals were bled for hematological assessment of malondialdehyde (MDA) and TNF-α and sacrificed on days 0, 1, 7, 14, and 21 after interventions for biomechanical, histological, and stereological studies. RESULTS: Stereologically speaking, in treatment groups an increase in dermal collagen volume and fibroblasts was noticed. In treatment groups, the length of vessels, angiogenesis, and skin stretch increased, but the wound area, MDA, and TNF-α level decreased. CONCLUSION: Mg cream was effective in healing burns.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quemaduras / Magnesio Límite: Animals Idioma: En Revista: Burns Asunto de la revista: TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quemaduras / Magnesio Límite: Animals Idioma: En Revista: Burns Asunto de la revista: TRAUMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos