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Generalized anxiety is a predictor of impaired quality of life in patients with atrial fibrillation: Findings from the prospective observational ARENA study.
Sadlonova, Monika; Salzmann, Stefan; Senges, Jochen; Celano, Christopher M; Huffman, Jeff C; Borggrefe, Martin; Akin, Ibrahim; Thomas, Dierk; Schwarzbach, Christopher Jan; Kleemann, Thomas; Schneider, Steffen; Hochadel, Matthias; Süselbeck, Tim; Schwacke, Harald; Alonso, Angelika; Haass, Markus; Ladwig, Karl-Heinz; Herrmann-Lingen, Christoph.
Afiliación
  • Sadlonova M; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany; Department of Cardiovascular and Thoracic Surgery, University of Göttingen Medical Center, Göttingen, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Göttingen,
  • Salzmann S; Department of Clinical Psychology and Psychotherapy, Philipps-University Marburg, Germany; Medical Psychology, Health and Medical University Erfurt, Germany.
  • Senges J; Institute of Myocardial Infarction Research, Hospital of Ludwigshafen, Ludwigshafen, Germany.
  • Celano CM; Department of Psychiatry, Massachusetts General Hospital, Boston, United States; Department of Psychiatry, Harvard Medical School, Boston, United States.
  • Huffman JC; Department of Psychiatry, Massachusetts General Hospital, Boston, United States; Department of Psychiatry, Harvard Medical School, Boston, United States.
  • Borggrefe M; Department of Cardiology, Pneumology, Angiology, and Emergency Medicine, University of Mannheim Medical Center, Mannheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Germany.
  • Akin I; Department of Cardiology, Pneumology, Angiology, and Emergency Medicine, University of Mannheim Medical Center, Mannheim, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Germany.
  • Thomas D; German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Germany; Department of Internal Medicine III - Cardiology, Angiology and Pneumology, Medical University, Hospital Heidelberg, Germany.
  • Schwarzbach CJ; Department of Neurology, Hospital of Ludwigshafen, Ludwigshafen, Germany.
  • Kleemann T; Hospital of Ludwigshafen, Ludwigshafen, Germany.
  • Schneider S; Institute of Myocardial Infarction Research, Hospital of Ludwigshafen, Ludwigshafen, Germany.
  • Hochadel M; Institute of Myocardial Infarction Research, Hospital of Ludwigshafen, Ludwigshafen, Germany.
  • Süselbeck T; Clinic of Cardiology, Ludwigshafen, Germany.
  • Schwacke H; Diakonissen-Stiftungs-Hospital Speyer, Speyer, Germany.
  • Alonso A; Department of Neurology, Mannheim Center for Translation Neuroscience, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Haass M; Department of Cardiology, Theresien Hospital and St. Hedwig Clinic GmbH, Mannheim, Germany.
  • Ladwig KH; Department of Psychosomatic Medicine and Psychotherapy, University Hospital rechts der Isar, Technical University Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
  • Herrmann-Lingen C; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center, Göttingen, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Germany.
J Psychosom Res ; 176: 111542, 2024 01.
Article en En | MEDLINE | ID: mdl-37977094
OBJECTIVE: Atrial fibrillation (AF) is associated with impaired health-related quality of life (HRQoL), an increased risk of morbidity, and mortality. Traditional AF-related outcomes (e.g., AF recurrence) primarily demonstrate the physiological benefits of AF management but do not focus on the benefits experienced subjectively by the patient (i.e., patient-reported outcomes), which have been suggested as optimal endpoints in AF intervention studies. The aim of this study is to identify medical and psychological factors associated with impaired HRQoL at 1-year follow-up. METHODS: Using data from the prospective observational multicenter ARENA study in patients with AF, we analyzed associations between medical factors, anxiety, and HRQoL at 1-year follow-up assessed using 5-level EuroQoL-5D. RESULTS: In 1353 AF patients (mean age 71.4 ± 10.3 years, 33.8% female), none of the medical predictors (e.g., heart disease) or history of cardioversion were associated with HRQoL at the 1-year follow-up. Higher generalized anxiety (ß = -0.114, p < .001) but not cardiac anxiety (ß = -0.006, p = .809) at baseline predicted decreased HRQoL, independent of confounding variables and patients' medical status. Furthermore, the worsening of patients' generalized anxiety was associated with decreased HRQoL (ß = -0.091, p < .001). In contrast, the improvement of generalized anxiety over time predicted higher HRQoL (ß = 0.097, p < .001). Finally, the worsening of patients' cardiac anxiety over time was associated with decreased HRQoL (ß = -0.081, p < .001). CONCLUSION: Our results highlight the importance of anxiety as a predictor of future HRQoL in patients with AF. Additional studies to examine the impact of anxiety treatment on HRQoL in this population are needed. CLINICAL TRIAL REGISTRATION: The investigators registered on ClinicalTrials.gov (NCT02978248) on November 30, 2016 https://clinicaltrials.gov/ct2/show/NCT02978248.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychosom Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Psychosom Res Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido