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Inflammation and renal function decline in chronic coronary syndrome: a prospective multicenter cohort study.
Kao, Ting-Wei; Huang, Chin-Chou; Leu, Hsin-Bang; Yin, Wei-Hsian; Tseng, Wei-Kung; Wu, Yen-Wen; Lin, Tsung-Hsien; Yeh, Hung-I; Chang, Kuan-Cheng; Wang, Ji-Hung; Wu, Chau-Chung; Chen, Jaw-Wen.
Afiliación
  • Kao TW; Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Huang CC; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Leu HB; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Yin WH; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. cchuang4@vghtpe.gov.tw.
  • Tseng WK; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. cchuang4@vghtpe.gov.tw.
  • Wu YW; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. cchuang4@vghtpe.gov.tw.
  • Lin TH; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Yeh HI; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chang KC; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Wang JH; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
  • Wu CC; Division of Cardiology, Heart Center, Cheng-Hsin General Hospital, Taipei, Taiwan.
  • Chen JW; Department of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung, Taiwan.
BMC Cardiovasc Disord ; 23(1): 564, 2023 11 16.
Article en En | MEDLINE | ID: mdl-37974082
BACKGROUND: Renal function decline is a frequently encountered complication in patients with chronic coronary syndrome. Aside from traditional cardiovascular risk factors, the inflammatory burden emerged as the novel phenotype that compromised renal prognosis in such population. METHODS: A cohort with chronic coronary syndrome was enrolled to investigate the association between inflammatory status and renal dysfunction. Levels of inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), tumour necrosis factor-α (TNF-α), adiponectin, matrix metalloproteinase-9, interleukin-6, lipoprotein-associated phospholipase A2, were assessed. Renal event was defined as > 25% decline in estimated glomerular filtration rate (eGFR). Inflammatory scores were calculated based on the aggregate of hs-CRP, TNF-α, and adiponectin levels. RESULTS: Among the 850 enrolled subjects, 145 patients sustained a renal event during an averaged 3.5 years follow-up. Multivariate analysis with Cox regression suggested elevations in hs-CRP, TNF-α, and adiponectin levels were independent risk factors for the occurrence of a renal event. Whereas, Kaplan-Meier curve illustrated significant correlation between high TNF-α (P = 0.005), adiponectin (P < 0.001), but not hs-CRP (P = 0.092), and eGFR decline. The aggregative effect of these biomarkers was also distinctly correlated with renal events (score 2: P = 0.042; score 3: P < 0.001). CONCLUSIONS: Inflammatory burden was associated with eGFR decline in patients with chronic coronary syndrome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Proteína C-Reactiva Límite: Humans Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Proteína C-Reactiva Límite: Humans Idioma: En Revista: BMC Cardiovasc Disord Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido