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Imaging of Myocardial αvß3 Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction.
Nammas, Wail; Paunonen, Christian; Teuho, Jarmo; Siekkinen, Reetta; Luoto, Pauliina; Käkelä, Meeri; Hietanen, Ari; Viljanen, Tapio; Dietz, Matthieu; Prior, John O; Li, Xiang-Guo; Roivainen, Anne; Knuuti, Juhani; Saraste, Antti.
Afiliación
  • Nammas W; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Paunonen C; Heart Center, Turku University Hospital, University of Turku, Turku, Finland.
  • Teuho J; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Siekkinen R; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Luoto P; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Käkelä M; Department of Medical Physics, Turku University Hospital, Turku, Finland.
  • Hietanen A; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Viljanen T; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Dietz M; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Prior JO; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Li XG; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
  • Roivainen A; Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
  • Knuuti J; Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
  • Saraste A; Department of Chemistry, University of Turku, Turku, Finland; and.
J Nucl Med ; 65(1): 132-138, 2024 Jan 02.
Article en En | MEDLINE | ID: mdl-37973184
[68Ga]Ga-NODAGA-Arg-Gly-Asp (RGD) is a PET tracer targeting αvß3 integrin, which is upregulated during angiogenesis soon after acute myocardial infarction (AMI). We prospectively evaluated determinants of myocardial uptake of [68Ga]Ga-NODAGA-RGD and its associations with left ventricular (LV) function in patients after AMI. Methods: Myocardial blood flow and [68Ga]Ga-NODAGA-RGD uptake (60 min after injection) were evaluated by PET in 31 patients 7.7 ± 3.8 d after primary percutaneous coronary intervention for ST-elevation AMI. Transthoracic echocardiography of LV function was performed on the day of PET and at the 6-mo follow-up. Results: PET images showed increased uptake of [68Ga]Ga-NODAGA-RGD in the ischemic area at risk (AAR), predominantly in injured myocardial segments. The SUV in the segment with the highest uptake (SUVmax) in the ischemic AAR was higher than the SUVmean of the remote myocardium (0.73 ± 0.16 vs. 0.51 ± 0.11, P < 0.001). Multivariable predictors of [68Ga]Ga-NODAGA-RGD uptake in the AAR included high peak N-terminal pro-B-type natriuretic peptide (P < 0.001), low LV ejection fraction, low global longitudinal strain (P = 0.01), and low longitudinal strain in the AAR (P = 0.01). [68Ga]Ga-NODAGA-RGD uptake corrected for myocardial blood flow and perfusable tissue fraction in the AAR predicted improvement in global longitudinal strain at follow-up (P = 0.002), independent of peak troponin, N-terminal pro-B-type natriuretic peptide, and LV ejection fraction. Conclusion: [68Ga]Ga-NODAGA-RGD uptake shows increased αvß3 integrin expression in the ischemic AAR early after AMI that is associated with regional and global systolic dysfunction, as well as increased LV filling pressure. Increased [68Ga]Ga-NODAGA-RGD uptake predicts improvement of global LV function 6 mo after AMI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina beta3 / Infarto del Miocardio Límite: Humans Idioma: En Revista: J Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Integrina beta3 / Infarto del Miocardio Límite: Humans Idioma: En Revista: J Nucl Med Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos