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Effect of systemic administration of Bifidobacterium animalis subsp. lactis HN019 on apical periodontitis.
Araujo, Lisa Danielly Curcino; Segato, Raquel Assed Bezerra; Reis, Thaís de Paula Colen; Salvador, Sérgio Luis de Souza; Furlaneto, Flávia Aparecida Chaves; Messora, Michel Reis; Nelson-Filho, Paulo; Almeida, Lana Kei Yamamoto de; Lucisano, Marília Pacífico; Silva, Clara Marina Pereira Cavalcanti; Silva, Léa Assed Bezerra da.
Afiliación
  • Araujo LDC; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Segato RAB; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Reis TPC; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Salvador SLS; Universidade de São Paulo - USP, School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analyses, Ribeirão Preto, SP, Brazil.
  • Furlaneto FAC; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirão Preto, SP, Brazil.
  • Messora MR; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Oral and Maxillofacial Surgery and Periodontology, Ribeirão Preto, SP, Brazil.
  • Nelson-Filho P; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Almeida LKY; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Lucisano MP; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Silva CMPC; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
  • Silva LABD; Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Pediatric Dentistry, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
Braz Oral Res ; 37: e115, 2023.
Article en En | MEDLINE | ID: mdl-37970935
This study aimed to evaluate the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019 in drinking water on the development of apical periodontitis (AP) in rats. In total 60 animals were divided into a control group (sound teeth); Group I - regular water without AP; Group II - probiotic water without AP; Group III - regular water with AP; Group IV - probiotic water with AP. AP was induced after 3 days in the control groups and after 7, 21, and 42 days in groups III and IV. The animals were euthanized, and the mandibles were subjected to histotechnical processing. Samples were stained with hematoxylin & eosin (H&E) to identify root canal features, apical and periapical regions. Additionally, histoenzymology was performed to detect osteoclasts, immunohistochemistry was used to identify osteoclastogenesis markers, and the Brown & Brenn technique was applied for microbiological analysis. The data were analyzed using GraphPad Prism 8.0.1 with a significance level of 5%. Although no statistical differences were observed, the groups administered with probiotics showed better conditions in terms of histological aspects seen microscopically. Furthermore, there were no differences in the number of osteoclasts (p > 0.05). The RANKL marker was not found in the probiotic group at 42 days, unlike in group III.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Probióticos / Bifidobacterium animalis Límite: Animals Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periodontitis Periapical / Probióticos / Bifidobacterium animalis Límite: Animals Idioma: En Revista: Braz Oral Res Asunto de la revista: ODONTOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil