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Polygonatum odoratum polysaccharide attenuates lipopolysaccharide-induced lung injury in mice by regulating gut microbiota.
Liu, Jia-Rui; Chen, Bo-Xue; Jiang, Mei-Ting; Cui, Tian-Yi; Lv, Bin; Fu, Zhi-Fei; Li, Xue; Du, Yao-Dong; Guo, Jin-He; Zhong, Xin-Qin; Zou, Ya-Dan; Zhao, Xin; Yang, Wen-Zhi; Gao, Xiu-Mei.
Afiliación
  • Liu JR; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Chen BX; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Jiang MT; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Cui TY; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Lv B; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Fu ZF; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Li X; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Du YD; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Guo JH; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Zhong XQ; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Zou YD; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Zhao X; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Yang WZ; State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China.
  • Gao XM; Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China.
Food Sci Nutr ; 11(11): 6974-6986, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37970373
Polygonatum odoratum is appreciated for its edible and medicinal benefits especially for lung protection. However, the contained active components have been understudied, and further research is required to fully exploit its potential application. We aimed to probe into the beneficial effects of Polygonatum odoratum polysaccharide (POP) in lipopolysaccharide-induced lung inflammatory injury mice. POP treatment could ameliorate the survival rate, pulmonary function, lung pathological lesions, and immune inflammatory response. POP treatment could repair intestinal barrier, and modulate the composition of gut microbiota, especially reducing the abundance of Klebsiella, which were closely associated with the therapeutic effects of POP. Investigation of the underlying anti-inflammatory mechanism showed that POP suppressed the generation of pro-inflammatory molecules in lung by inhibiting iNOS+ M1 macrophages. Collectively, POP is a promising multi-target microecological regulator to prevent and treat the immuno-inflammation and lung injury by modulating gut microbiota.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Nutr Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Food Sci Nutr Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos