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Cortical microglia dynamics are conserved during voluntary wheel running.
Strohm, Alexandra O; O'Connor, Thomas N; Oldfield, Sadie; Young, Sala; Hammond, Christian; McCall, Matthew; Dirksen, Robert T; Majewska, Ania K.
Afiliación
  • Strohm AO; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.
  • O'Connor TN; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States.
  • Oldfield S; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States.
  • Young S; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, United States.
  • Hammond C; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, United States.
  • McCall M; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States.
  • Dirksen RT; Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States.
  • Majewska AK; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States.
J Appl Physiol (1985) ; 136(1): 89-108, 2024 Jan 01.
Article en En | MEDLINE | ID: mdl-37969082
We present the first demonstration of chronic in vivo imaging of microglia in mice undergoing voluntary wheel running. We find that healthy mice undergoing voluntary wheel running have similar microglia dynamics, morphologies, and responses to injury when compared to sedentary mice. This suggests that exercise over a period of 1 mo does not grossly alter cortical microglial phenotypes and that exercise may exert its beneficial effects on the brain through other mechanisms. Future work examining how microglia dynamics may be altered during exercise in disease or injury models could provide further insights into the therapeutic benefit of exercise.NEW & NOTEWORTHY We demonstrate the first use of chronic in vivo imaging of microglia over time during physical exercise. We found that microglia movement, morphology, and process motility were remarkably stable during voluntary wheel running (VWR). Additionally, microglia in running mice respond similarly to laser ablation injury compared to sedentary mice. These findings indicate that VWR does not induce changes in microglia dynamics in healthy adults. Exercise may elicit positive effects on the brain through other mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Microglía Límite: Animals / Humans Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Microglía Límite: Animals / Humans Idioma: En Revista: J Appl Physiol (1985) Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos