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Effects of propylene glycol used at different doses in Akkaraman lambs rations on metabolism-related parameters and liver gene and protein expression during different feeding periods.
Yakan, Akin; Özkan, Hüseyin; Kaya, Ufuk; Keçeli, Hasan Hüseyin; Dalkiran, Sevda; Karaaslan, Irem; Ünal, Necmettin; Akçay, Aytaç; Arslan, Korhan; Akyüz, Bilal; Güngör, Güven; Çamdeviren, Baran; Küçükoflaz, Mehmet; Sariözkan, Savas; Özbeyaz, Ceyhan.
Afiliación
  • Yakan A; Faculty of Veterinary Medicine, Department of Genetics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Özkan H; Faculty of Veterinary Medicine, Department of Genetics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Kaya U; Faculty of Veterinary Medicine, Department of Biostatistics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Keçeli HH; Faculty of Veterinary Medicine, Department of Genetics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Dalkiran S; Institute of Health Sciences, Department of Molecular Biochemistry and Genetics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Karaaslan I; Technology and Research & Development Center (MARGEM), Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Ünal N; Faculty of Veterinary Medicine, Department of Animal Science, Ankara University, Ankara, Turkiye.
  • Akçay A; Faculty of Veterinary Medicine, Department of Biostatistics, Ankara University, Ankara, Turkiye.
  • Arslan K; Faculty of Veterinary Medicine, Department of Genetics, Erciyes University, Kayseri, Turkiye.
  • Akyüz B; Faculty of Veterinary Medicine, Department of Genetics, Erciyes University, Kayseri, Turkiye.
  • Güngör G; Faculty of Veterinary Medicine, Department of Biostatistics, Erciyes University, Kayseri, Turkiye.
  • Çamdeviren B; Institute of Health Sciences, Department of Molecular Biochemistry and Genetics, Hatay Mustafa Kemal University, Antakya, Hatay, Turkiye.
  • Küçükoflaz M; Faculty of Veterinary Medicine, Department of Animal Health Economics and Management, Kafkas University, Kars, Turkiye.
  • Sariözkan S; Faculty of Veterinary Medicine, Department of Animal Health Economics and Management, Erciyes University, Kayseri, Turkiye.
  • Özbeyaz C; Faculty of Veterinary Medicine, Department of Animal Science, Ankara University, Ankara, Turkiye.
Anim Sci J ; 94(1): e13886, 2023.
Article en En | MEDLINE | ID: mdl-37963598
This study aimed to investigate the metabolic effects of propylene glycol (PG) over 60, 90, and 120 days in lambs. Seventy-two weaned male lambs were allocated into three groups: control (Con), PG1.5 (1.5 mL/kg live weight0.75 ), and PG3 (3 mL/kg live weight0.75 ). Blood samples were collected at the beginning and slaughter days. Biochemical parameters (glucose, triglycerides, ALT, AST, LDH, BUN, and insulin) and gene and protein levels of peroxisome proliferator activated receptor gamma (PPARγ), diacylglycerol o-acyltransferase 1 (DGAT1), carbohydrate responsive element binding protein (ChREBP), and sterol regulatory element binding transcription factor 1c (SREBP-1c) in the liver were determined. Glucose in PG1.5 was increased on Day 60, while significant differences were observed in biochemical parameters except for insulin on the 60, 90, and 120 days. Biochemical parameters such as ALT, AST, LDH, and BUN increased over time, while triglycerides decreased. DGAT1 gene and protein levels were lower, while SREBP-1c and PPARγ were higher in PG groups on Day 60. While SREBP-1c was lower in PG1.5, ChREBP was higher in PG3 on Day 90. PPARγ, DGAT1, and ChREBP were upregulated in PG3 on Day 120. Positive correlations were found between proteins. The long-term use of PG in lambs did not have detrimental effects on metabolism. The study provides valuable insights into the molecular mechanisms underlying the metabolic effects of PG in lambs, shedding light on its potential applications in lamb production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: PPAR gamma / Hígado Límite: Animals Idioma: En Revista: Anim Sci J Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article Pais de publicación: Australia
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: PPAR gamma / Hígado Límite: Animals Idioma: En Revista: Anim Sci J Asunto de la revista: MEDICINA VETERINARIA Año: 2023 Tipo del documento: Article Pais de publicación: Australia