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Anti-inflammatory labdane diterpenoids from the aerial parts of Leonurus sibiricus.
Li, Jiahang; Niu, Lihang; Huang, Hong; Li, Qing; Xie, Chunfeng; Yang, Cheng.
Afiliación
  • Li J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China; Tianjin International Joint Academy of Biomedicine, Tianjin, 300457, China.
  • Niu L; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
  • Huang H; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China; Tianjin International Joint Academy of Biomedicine, Tianjin, 300457, China.
  • Li Q; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China; Tianjin International Joint Academy of Biomedicine, Tianjin, 300457, China.
  • Xie C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China. Electronic address: xiechunfeng@nankai.edu.cn.
  • Yang C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China. Electronic address: cheng.yang@nankai.edu.cn.
Phytochemistry ; 217: 113927, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37956887
ABSTRACT
Eleven undescribed labdane diterpenoids, sibiricusins K-U, and seven known analogues were obtained from the MeOH extract of the aerial parts of Leonurus sibiricus. The structures of the compounds were established by detailed spectroscopic data analysis, single-crystal X-ray diffraction analysis and ECD calculations. Among them, sibiricusins L-N featured a rare α, ß-unsaturated-γ-lactam moiety. Fourteen of the isolates were evaluated for their anti-inflammatory effect on the production of NO in LPS-induced RAW264.7 cells through Griess assay. Sibiricusin O displayed the strongest activity with an IC50 value of 9.0 ± 1.7 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leonurus / Diterpenos Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leonurus / Diterpenos Idioma: En Revista: Phytochemistry Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido