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Impact of corpus callosum integrity on functional interhemispheric connectivity and cognition in healthy subjects.
Porcu, Michele; Cocco, Luigi; Marrosu, Francesco; Cau, Riccardo; Suri, Jasjit S; Qi, Yang; Pineda, Victor; Bosin, Andrea; Malloci, Giuliano; Ruggerone, Paolo; Puig, Josep; Saba, Luca.
Afiliación
  • Porcu M; Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy. micheleporcu87@gmail.com.
  • Cocco L; Department of Medical Imaging, Azienda Ospedaliera Universitaria di Cagliari, S.S: 554, Km 4,500 - CAP, Monserrato, 09042, Cagliari, Italy. micheleporcu87@gmail.com.
  • Marrosu F; Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy.
  • Cau R; Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy.
  • Suri JS; Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy.
  • Qi Y; Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA.
  • Pineda V; Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China.
  • Bosin A; Department of Medical Sciences, Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain.
  • Malloci G; Department of Radiology (IDI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain.
  • Ruggerone P; Department of Physics, University of Cagliari, Cagliari, Italy.
  • Puig J; Department of Physics, University of Cagliari, Cagliari, Italy.
  • Saba L; Department of Physics, University of Cagliari, Cagliari, Italy.
Brain Imaging Behav ; 18(1): 141-158, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37955809
To examine the corpus callosum's (CC) integrity in terms of fractional anisotropy (FA) and how it affects resting-state hemispheric connectivity (rs-IHC) and cognitive function in healthy individuals. Sixty-eight healthy individuals were recruited for the study. The global FA (gFA) and FA values of each CC tract (forceps minor, body, tapetum, and forceps major) were evaluated using diffusion-weighted imaging (DWI) sequences. The homotopic functional connectivity technique was used to quantify the effects of FA in the CC tracts on bilateral functional connectivity, including the confounding effect of gFA. Brain regions with higher or lower rs-IHC were identified using the threshold-free cluster enhancement family-wise error-corrected p-value of 0.05. The null hypothesis was rejected if the p-value was ≤ 0.05 for the nonparametric partial correlation technique. Several clusters of increased rs-IHC were identified in relation to the FA of individual CC tracts, each with a unique topographic distribution and extension. Only forceps minor FA values correlated with cognitive scores. The integrity of CC influences rs-IHC differently in healthy subjects. Specifically, forceps minor anisotropy impacts rs-IHC and cognition more than other CC tracts do.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Imagen de Difusión Tensora Límite: Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Imagen de Difusión Tensora Límite: Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos