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Brazilian Green Propolis' Artepillin C and Its Acetylated Derivative Activate the NGF-Signaling Pathways and Induce Neurite Outgrowth in NGF-Deprived PC12 Cells.
Rocha Caldas, Gabriel; do Amaral, Lilian; Munhoz Rodrigues, Débora; Mayrink de Miranda, Aline; Aparecida Guinaim Dos Santos, Neife; Machado Rocha, Leandro; Tame Parreira, Renato Luis; Cardozo Dos Santos, Antônio; Kenupp Bastos, Jairo.
Afiliación
  • Rocha Caldas G; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • do Amaral L; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Munhoz Rodrigues D; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Mayrink de Miranda A; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Aparecida Guinaim Dos Santos N; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Machado Rocha L; Natural Products Technology Laboratory-Fluminense Federal University, Niterói, RJ, Brazil.
  • Tame Parreira RL; Research Center in Exact and Technological Sciences, Franca University, Franca, SP, Brazil.
  • Cardozo Dos Santos A; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
  • Kenupp Bastos J; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Chem Biodivers ; 20(12): e202301294, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37953436
Artepillin C is the most studied compound in Brazilian Green Propolis and, along with its acetylated derivative, displays neurotrophic activity on PC12 cells. Specific inhibitors of the trkA receptor (K252a), PI3K/Akt (LY294002), and MAPK/ERK (U0126) signaling pathways were used to investigate the neurotrophic mechanism. The expression of proteins involved in axonal and synaptic plasticity (GAP-43 and Synapsin I) was assessed by western blotting. Additionally, physicochemical properties, pharmacokinetics, and drug-likeness were evaluated by the SwissADME web tool. Both compounds induced neurite outgrowth by activating the NGF-signaling pathways but through different neuronal proteins. Furthermore, in silico analyses showed interesting physicochemical and pharmacokinetic properties of these compounds. Therefore, these compounds could play an important role in axonal and synaptic plasticity and should be further investigated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Própolis Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza