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Increased risk of chronic fatigue syndrome following infection: a 17-year population-based cohort study.
Chang, Hsun; Kuo, Chien-Feng; Yu, Teng-Shun; Ke, Liang-Yin; Hung, Chung-Lieh; Tsai, Shin-Yi.
Afiliación
  • Chang H; Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
  • Kuo CF; Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
  • Yu TS; Department of Medicine, MacKay Medical College, New Taipei City, 252, Taiwan.
  • Ke LY; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
  • Hung CL; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
  • Tsai SY; Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
J Transl Med ; 21(1): 804, 2023 11 11.
Article en En | MEDLINE | ID: mdl-37951920
BACKGROUND: Previous serological studies have indicated an association between viruses and atypical pathogens and Chronic Fatigue Syndrome (CFS). This study aims to investigate the correlation between infections from common pathogens, including typical bacteria, and the subsequent risk of developing CFS. The analysis is based on data from Taiwan's National Health Insurance Research Database. METHODS: From 2000 to 2017, we included a total of 395,811 cases aged 20 years or older newly diagnosed with infection. The cases were matched 1:1 with controls using a propensity score and were followed up until diagnoses of CFS were made. RESULTS: The Cox proportional hazards regression analysis was used to estimate the relationship between infection and the subsequent risk of CFS. The incidence density rates among non-infection and infection population were 3.67 and 5.40 per 1000 person-years, respectively (adjusted hazard ratio [HR] = 1.5, with a 95% confidence interval [CI] 1.47-1.54). Patients infected with Varicella-zoster virus, Mycobacterium tuberculosis, Escherichia coli, Candida, Salmonella, Staphylococcus aureus and influenza virus had a significantly higher risk of CFS than those without these pathogens (p < 0.05). Patients taking doxycycline, azithromycin, moxifloxacin, levofloxacin, or ciprofloxacin had a significantly lower risk of CFS than patients in the corresponding control group (p < 0.05). CONCLUSION: Our population-based retrospective cohort study found that infection with common pathogens, including bacteria, viruses, is associated with an increased risk of developing CFS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Límite: Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Fatiga Crónica Límite: Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido