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Sex and age differences in social and cognitive function in offspring exposed to late gestational hypoxia.
Mabry, Steve; Wilson, E Nicole; Bradshaw, Jessica L; Gardner, Jennifer J; Fadeyibi, Oluwadarasimi; Vera, Edward; Osikoya, Oluwatobiloba; Cushen, Spencer C; Karamichos, Dimitrios; Goulopoulou, Styliani; Cunningham, Rebecca L.
Afiliación
  • Mabry S; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Wilson EN; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Bradshaw JL; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Gardner JJ; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Fadeyibi O; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
  • Vera E; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Osikoya O; Department of Pharmaceutical Sciences, School of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX, 76107, USA.
  • Cushen SC; Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
  • Karamichos D; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
  • Goulopoulou S; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
  • Cunningham RL; Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Biol Sex Differ ; 14(1): 81, 2023 11 11.
Article en En | MEDLINE | ID: mdl-37951901
Sleep apnea during late pregnancy is a common pregnancy complication that can impact the brain development of children born to mothers with sleep apnea. Children with impaired brain development may present with decreased social skills, memory issues, anxiety, and compulsivity. It is unclear if there is a cause and effect relationship between sleep apnea during late pregnancy and behavioral changes in offspring. Additionally, it is unknown whether male or female sex or age of the offspring affects these relationships. In this study, we exposed pregnant rats to a model of sleep apnea called chronic intermittent hypoxia (CIH) within late gestation and examined the behavior of the offspring and brain activity during puberty and young adulthood. We found that CIH during late pregnancy had long-term effects in the offspring that were different in males and females. Notably, female offspring displayed social impairments in response to late gestation CIH, whereas male offspring displayed cognitive dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de la Apnea del Sueño / Corticosterona Límite: Animals / Pregnancy Idioma: En Revista: Biol Sex Differ Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de la Apnea del Sueño / Corticosterona Límite: Animals / Pregnancy Idioma: En Revista: Biol Sex Differ Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido