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DAT1 and BDNF polymorphisms interact to predict Aß and tau pathology.
Ciampa, Claire J; Morin, Thomas M; Murphy, Alice; Joie, Renaud La; Landau, Susan M; Berry, Anne S.
Afiliación
  • Ciampa CJ; Department of Biology, Brandeis University, Waltham, MA 02453, USA. Electronic address: claireciampa@brandeis.edu.
  • Morin TM; Department of Psychology, Brandeis University, Waltham, MA 02453, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02155, USA.
  • Murphy A; Hellen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
  • Joie R; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
  • Landau SM; Hellen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  • Berry AS; Department of Psychology, Brandeis University, Waltham, MA 02453, USA; Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.
Neurobiol Aging ; 133: 115-124, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37948982
ABSTRACT
Previous work has associated polymorphisms in the dopamine transporter gene (rs6347 in DAT1/SLC6A3) and brain derived neurotrophic factor gene (Val66Met in BDNF) with atrophy and memory decline. However, it is unclear whether these polymorphisms relate to atrophy and cognition through associations with Alzheimer's disease pathology. We tested for effects of DAT1 and BDNF polymorphisms on cross-sectional and longitudinal ß-amyloid (Aß) and tau pathology (measured with positron emission tomography (PET)), hippocampal volume, and cognition. We analyzed a sample of cognitively normal older adults (cross-sectional n = 321) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). DAT1 and BDNF interacted to predict Aß-PET, tau-PET, and hippocampal atrophy. Carriers of both "non-boptimal" DAT1 C and BDNF Met alleles demonstrated greater pathology and atrophy. Our findings provide novel links between dopamine and neurotrophic factor genes and AD pathology, consistent with previous research implicating these variants in greater risk for developing AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Aged / Humans Idioma: En Revista: Neurobiol Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Disfunción Cognitiva Límite: Aged / Humans Idioma: En Revista: Neurobiol Aging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos