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Effect of preoperative chemotherapy on the histopathological classification of gastric cancer.
Caspers, I A; Biesma, H D; Wiklund, K; Pontén, F; Lind, P; Nordsmark, M; Sikorska, K; Meershoek-KleinKranenbarg, E; Hartgrink, H H; van de Velde, C J H; van Sandick, J W; Verheij, M; Cats, A; van Grieken, N C T.
Afiliación
  • Caspers IA; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Antoni Van Leeuwenhoek, Amsterdam, The Netherlands.
  • Biesma HD; Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, the Netherlands.
  • Wiklund K; Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, the Netherlands.
  • Pontén F; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
  • Lind P; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
  • Nordsmark M; Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
  • Sikorska K; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Meershoek-KleinKranenbarg E; Department of Biometrics, Netherlands Cancer Institute, Antoni Van Leeuwenhoek, Amsterdam, The Netherlands.
  • Hartgrink HH; Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • van de Velde CJH; Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • van Sandick JW; Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
  • Verheij M; Department of Surgical Oncology, Netherlands Cancer Institute, Antoni Van Leeuwenhoek, Amsterdam, The Netherlands.
  • Cats A; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Grieken NCT; Department of Radiation Oncology, Netherlands Cancer Institute, Antoni Van Leeuwenhoek, Amsterdam, The Netherlands.
Gastric Cancer ; 27(1): 102-109, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37947918
BACKGROUND: In the era of individualized gastric cancer (GC) treatment, accurate determination of histological subtype becomes increasingly relevant. As yet, it is unclear whether preoperative chemotherapy may affect the histological subtype. The aim of this study was to assess concordance in histological subtype between pretreatment biopsies and surgical resection specimens before and after the introduction of perioperative treatment. METHODS: Histological subtype was centrally determined in paired GC biopsies and surgical resection specimens of patients treated with either surgery alone (SA) in the Dutch D1/D2 study or with preoperative chemotherapy (CT) in the CRITICS trial. The histological subtype as determined in the resection specimen was considered the gold standard. Concordance rates and sensitivity and specificity of intestinal, diffuse, mixed, and "other" subtypes of GC were analyzed. RESULTS: In total, 105 and 515 pairs of GC biopsies and resection specimens of patients treated in the SA and CT cohorts, respectively, were included. Overall concordance in the histological subtype was 72% in the SA and 74% in the CT cohort and substantially higher in the diffuse subtype (83% and 86%) compared to the intestinal (70% and 74%), mixed (21% and 33%) and "other" subtypes (54% and 54%). In the SA cohort, sensitivities and specificities were 0.88 and 0.71 in the intestinal, 0.67 and 0.93 in the diffuse, 0.20 and 0.98 in the mixed, and 0.50 and 0.93 in the "other" subtypes, respectively. CONCLUSION: Our results suggest that accurate determination of histological subtype on gastric cancer biopsies is suboptimal but that the impact of preoperative chemotherapy on histological subtype is negligible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma Límite: Humans Idioma: En Revista: Gastric Cancer Asunto de la revista: GASTROENTEROLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Adenocarcinoma Límite: Humans Idioma: En Revista: Gastric Cancer Asunto de la revista: GASTROENTEROLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Japón