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Cancer-Related Fatigue and Circulating Biomarkers in Breast Cancer Survivors.
García-González, David; Romero-Elías, María; Álvarez-Bustos, Alejandro; Rosado-García, Silvia; Sánchez-López, Antonio J; Cantos, Blanca; Maximiano, Constanza; Méndez, Miriam; Méndez-Otero, Marta; Cebolla, Héctor; García-Foncillas, Jesús; Ruiz-Casado, Ana.
Afiliación
  • García-González D; School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • Romero-Elías M; Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Álvarez-Bustos A; Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain.
  • Rosado-García S; Biobank, Puerta de Hierro-Segovia de Arana Health Research Institute, Madrid, Spain.
  • Sánchez-López AJ; Biobank, Puerta de Hierro-Segovia de Arana Health Research Institute, Madrid, Spain.
  • Cantos B; Department of Medical Oncology, IDIPHISA, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Maximiano C; Department of Medical Oncology, IDIPHISA, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Méndez M; Department of Medical Oncology, IDIPHISA, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Méndez-Otero M; Department of Medical Oncology, IDIPHISA, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
  • Cebolla H; Spanish National Research Council (CSIC), Madrid, Spain.
  • García-Foncillas J; School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  • Ruiz-Casado A; Translational Oncology Division, Oncohealth Institute, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain.
Biol Res Nurs ; 26(2): 270-278, 2024 Apr.
Article en En | MEDLINE | ID: mdl-37947791
PURPOSE: Cancer-related fatigue (CRF) is the most common and disruptive symptom experienced by cancer survivors and because of its frequency and severity is especially worrisome in breast cancer survivors (BCS). Despite a great deal of research, the mechanisms underlying CRF have not been determined. The present study aims to describe associations between CRF in BCS and different blood biomarkers. METHODS: A descriptive and cross-sectional study was conducted. A set of biomarkers assessing inflammation were measured in BCS: C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), IL-1ß, IL-6, IL-8, IL-10, tumor necrosis factor (TNF); HPA axis dysfunction (cortisol), autonomic dysfunction (noradrenaline); oxidative stress (8-OH deoxyguanosine); insulin resistance markers (insulin, IGF-I, IGFBP3) and sexual hormones (estrogens, progesterone, testosterone). RESULTS: NLR (p = .00) and cortisol (p = .02) were positive and negatively associated with CRF, respectively. The rest of the blood markers were not associated with CRF. CONCLUSION: Our results increase the evidence on pathophysiological mechanisms driving CRF in BCS. However, longitudinal studies are needed to explore the role of these factors as potential causal mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Supervivientes de Cáncer Límite: Female / Humans Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Supervivientes de Cáncer Límite: Female / Humans Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos