Your browser doesn't support javascript.
loading
EMT and primary ciliogenesis: For better or worse in sickness and in health.
Tessier, Camille E; Dupuy, Aurore M M; Pelé, Thomas; Juin, Philippe P; Lees, Jacqueline A; Guen, Vincent J.
Afiliación
  • Tessier CE; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
  • Dupuy AMM; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
  • Pelé T; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
  • Juin PP; Nantes Université, Inserm, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
  • Lees JA; ICO René Gauducheau, Saint Herblain, France.
  • Guen VJ; Koch Institute for Integrative Cancer Research @ MIT, Cambridge, Massachusetts, USA.
Genesis ; 62(1): e23568, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37946671
Epithelial-mesenchymal transition (EMT) and primary ciliogenesis are two cell-biological programs that are essential for development of multicellular organisms and whose abnormal regulation results in many diseases (i.e., developmental anomalies and cancers). Emerging studies suggest an intricate interplay between these two processes. Here, we discuss physiological and pathological contexts in which their interconnections promote normal development or disease progression. We describe underlying molecular mechanisms of the interplay and EMT/ciliary signaling axes that influence EMT-related processes (i.e., stemness, motility and invasion). Understanding the molecular and cellular mechanisms of the relationship between EMT and primary ciliogenesis may provide new insights in the etiology of diseases related to EMT and cilia dysfunction.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transición Epitelial-Mesenquimal / Neoplasias Límite: Humans Idioma: En Revista: Genesis Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transición Epitelial-Mesenquimal / Neoplasias Límite: Humans Idioma: En Revista: Genesis Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos