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Present and future of metabolic and metabolomics studies focused on classical psychedelics in humans.
Madrid-Gambin, Francisco; Fabregat-Safont, David; Gomez-Gomez, Alex; Olesti, Eulàlia; Mason, Natasha L; Ramaekers, Johannes G; Pozo, Oscar J.
Afiliación
  • Madrid-Gambin F; Applied Metabolomics Research Group, Hospital del Mar Research Institute, 08003 Barcelona, Spain. Electronic address: fmadrid@imim.es.
  • Fabregat-Safont D; Applied Metabolomics Research Group, Hospital del Mar Research Institute, 08003 Barcelona, Spain; Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, 12071 Castelló, Spain.
  • Gomez-Gomez A; Applied Metabolomics Research Group, Hospital del Mar Research Institute, 08003 Barcelona, Spain; CERBA Internacional, Chromatography Department, 08203 Sabadell, Spain.
  • Olesti E; Department of Clinical Pharmacology, Area Medicament, Hospital Clinic of Barcelona, 08036 Barcelona, Spain; Clinical Pharmacology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
  • Mason NL; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, the Netherlands.
  • Ramaekers JG; Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, the Netherlands.
  • Pozo OJ; Applied Metabolomics Research Group, Hospital del Mar Research Institute, 08003 Barcelona, Spain. Electronic address: opozo@imim.es.
Biomed Pharmacother ; 169: 115775, 2023 Dec 31.
Article en En | MEDLINE | ID: mdl-37944438
Psychedelics are classical hallucinogen drugs that induce a marked altered state of consciousness. In recent years, there has been renewed attention to the possible use of classical psychedelics for the treatment of certain mental health disorders. However, further investigation to better understand their biological effects in humans, their mechanism of action, and their metabolism in humans is needed when considering the development of future novel therapeutic approaches. Both metabolic and metabolomics studies may help for these purposes. On one hand, metabolic studies aim to determine the main metabolites of the drug. On the other hand, the application of metabolomics in human psychedelics studies can help to further understand the biological processes underlying the psychedelic state and the mechanisms of action underlying their therapeutic potential. This review presents the state of the art of metabolic and metabolomic studies after lysergic acid diethylamide (LSD), mescaline, N,N-dimethyltryptamine (DMT) and ß-carboline alkaloids (ayahuasca brew), 5-methoxy-DMT and psilocybin administrations in humans. We first describe the characteristics of the published research. Afterward, we reviewed the main results obtained by both metabolic and metabolomics (if available) studies in classical psychedelics and we found out that metabolic and metabolomics studies in psychedelics progress at two different speeds. Thus, whereas the main metabolites for classical psychedelics have been robustly established, the main metabolic alterations induced by psychedelics need to be explored. The integration of metabolomics and pharmacokinetics for investigating the molecular interaction between psychedelics and multiple targets may open new avenues in understanding the therapeutic role of psychedelics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alucinógenos / Trastornos Mentales Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alucinógenos / Trastornos Mentales Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article Pais de publicación: Francia