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Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients.
Dos Santos, Stephany Bonin Godinho; da Silva, Janaína Carla; Jaques, Hellen Dos Santos; Dalla Vecchia, Marina Ferronato; Ferreira, Mariane Okamoto; Rech, Daniel; Sierota da Silva, Matheus Ryan Noah; Dos Santos, Roberta Bonin Godinho; Panis, Carolina; Benvegnú, Dalila Moter.
Afiliación
  • Dos Santos SBG; Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • da Silva JC; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Jaques HDS; Laboratório de Biologia de Tumores, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Dalla Vecchia MF; Laboratório de Biologia de Tumores, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Ferreira MO; Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Rech D; Laboratório de Biologia de Tumores, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Sierota da Silva MRN; Programa de Pós-Graduação em Ciências Aplicadas à Saúde, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Dos Santos RBG; Laboratório de Biologia de Tumores, Universidade Estadual do Oeste do Paraná, Francisco Beltrão, Paraná, Brazil.
  • Panis C; Department of Surgery, Hospital de Câncer de Francisco Beltrão, Francisco Beltrão, Paraná, Brazil.
  • Benvegnú DM; Curso de Graduação em Engenharia Ambiental e Sanitária, Universidade Tecnológica Federal do Paraná, Francisco Beltrão, Paraná, Brazil.
Front Immunol ; 14: 1281056, 2023.
Article en En | MEDLINE | ID: mdl-37942322
Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1ß, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Neoplasias de la Mama / Exposición Profesional Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Neoplasias de la Mama / Exposición Profesional Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza