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Purification, characterization, and cloning of a novel pro-inflammatory secreted protein from Staphylococcus aureus.
Schlievert, Patrick M; Nelson, Jacob D; Kilgore, Samuel H; Radoshevich, Lilliana; Klingelhutz, Aloysius J; Leung, Donald Y M.
Afiliación
  • Schlievert PM; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
  • Nelson JD; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
  • Kilgore SH; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
  • Radoshevich L; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
  • Klingelhutz AJ; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa , Iowa City, Iowa, USA.
  • Leung DYM; Department of Pediatrics, National Jewish Health , Denver, Colorado, USA.
Microbiol Spectr ; 11(6): e0289823, 2023 Dec 12.
Article en En | MEDLINE | ID: mdl-37937984
IMPORTANCE: Staphylococcus aureus causes a myriad of human diseases, ranging from relatively mild soft tissue infections to highly fatal pneumonia, sepsis, and toxic shock syndrome. The organisms primarily cause diseases across mucosal and skin barriers. In order to facilitate penetration of barriers, S. aureus causes harmful inflammation by inducing chemokines from epithelial cells. We report the cloning and characterization of a novel secreted S. aureus protein that induces chemokine production from epithelial cells as its major demonstrable function. This secreted protein possibly helps S. aureus and its secreted proteins to penetrate host barriers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Límite: Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Límite: Humans Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos