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Number of children in the household influences respiratory morbidities in children with bronchopulmonary dysplasia in the outpatient setting.
Collaco, Joseph M; Tsukahara, Katharine R; Tracy, Michael C; Sheils, Catherine A; Rice, Jessica L; Rhein, Lawrence M; Popova, Antonia P; Nelin, Leif; Miller, Audrey N; Manimtim, Winston M; Levin, Jonathan C; Lai, Khanh; Kaslow, Jacob A; Hayden, Lystra P; Bansal, Manvi; Austin, Eric D; Aoyama, Brianna; Akangire, Gangaram; Agarwal, Amit; Villafranco, Natalie; McGrath-Morrow, Sharon A.
Afiliación
  • Collaco JM; Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
  • Tsukahara KR; Division of Pediatric Pulmonary and Sleep Medicine, University of Utah, Salt Lake City, Utah, USA.
  • Tracy MC; Division of Pediatric Pulmonary, Asthma and Sleep Medicine, Stanford University, Stanford, California, USA.
  • Sheils CA; Division of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Rice JL; Division of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rhein LM; Department of Neonatal-Perinatal Medicine/Pediatric Pulmonology, University of Massachusetts, Worcester, Massachusetts, USA.
  • Popova AP; Department of Pediatric Pulmonology, University of Michigan, Ann Arbor, Michigan, USA.
  • Nelin L; Division of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, Ohio, USA.
  • Miller AN; Division of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, Ohio, USA.
  • Manimtim WM; Division of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
  • Levin JC; Division of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Lai K; Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Kaslow JA; Division of Pediatric Pulmonary and Sleep Medicine, University of Utah, Salt Lake City, Utah, USA.
  • Hayden LP; Department of Pulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Bansal M; Division of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Austin ED; Department of Pulmonology and Sleep Medicine, Children's Hospital of Los Angeles, Los Angeles, California, USA.
  • Aoyama B; Department of Pulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Akangire G; Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
  • Agarwal A; Division of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
  • Villafranco N; Division of Pulmonary Medicine, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • McGrath-Morrow SA; Department of Pulmonary Medicine, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, USA.
Pediatr Pulmonol ; 59(2): 314-322, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37937888
BACKGROUND: Bronchopulmonary dysplasia (BPD), a common complication of prematurity, is associated with outpatient morbidities, including respiratory exacerbations. Daycare attendance is associated with increased rates of acute and chronic morbidities in children with BPD. We sought to determine if additional children in the household conferred similar risks for children with BPD. METHODS: The number of children in the household and clinical outcomes were obtained via validated instruments for 933 subjects recruited from 13 BPD specialty clinics in the United States. Clustered logistic regression models were used to test for associations. RESULTS: The mean gestational age of the study population was 26.5 ± 2.2 weeks and most subjects (69.1%) had severe BPD. The mean number of children in households (including the subject) was 2.1 ± 1.3 children. Each additional child in the household was associated with a 13% increased risk for hospital admission, 13% increased risk for antibiotic use for respiratory illnesses, 10% increased risk for coughing/wheezing/shortness of breath, 14% increased risk for nighttime symptoms, and 18% increased risk for rescue medication use. Additional analyses found that the increased risks were most prominent when there were three or more other children in the household. CONCLUSIONS: We observed that additional children in the household were a risk factor for adverse respiratory outcomes. We speculate that secondary person-to-person transmission of respiratory viral infections drives this finding. While this risk factor is not easily modified, measures do exist to mitigate this disease burden. Further studies are needed to define best practices for mitigating this risk associated with household viral transmission.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar Límite: Child / Humans / Infant / Newborn Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar Límite: Child / Humans / Infant / Newborn Idioma: En Revista: Pediatr Pulmonol Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos