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Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging.
Cohn, David E; Forder, Aisling; Marshall, Erin A; Vucic, Emily A; Stewart, Greg L; Noureddine, Kouther; Lockwood, William W; MacAulay, Calum E; Guillaud, Martial; Lam, Wan L.
Afiliación
  • Cohn DE; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Forder A; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Marshall EA; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Vucic EA; Department of Biochemistry and Molecular Pharmacology, New York University (NYU) Langone Medical Center, New York, NY, United States.
  • Stewart GL; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Noureddine K; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Lockwood WW; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • MacAulay CE; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Guillaud M; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
  • Lam WL; Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.
Front Immunol ; 14: 1275890, 2023.
Article en En | MEDLINE | ID: mdl-37936700
The growth and metastasis of solid tumours is known to be facilitated by the tumour microenvironment (TME), which is composed of a highly diverse collection of cell types that interact and communicate with one another extensively. Many of these interactions involve the immune cell population within the TME, referred to as the tumour immune microenvironment (TIME). These non-cell autonomous interactions exert substantial influence over cell behaviour and contribute to the reprogramming of immune and stromal cells into numerous pro-tumourigenic phenotypes. The study of some of these interactions, such as the PD-1/PD-L1 axis that induces CD8+ T cell exhaustion, has led to the development of breakthrough therapeutic advances. Yet many common analyses of the TME either do not retain the spatial data necessary to assess cell-cell interactions, or interrogate few (<10) markers, limiting the capacity for cell phenotyping. Recently developed digital pathology technologies, together with sophisticated bioimage analysis programs, now enable the high-resolution, highly-multiplexed analysis of diverse immune and stromal cell markers within the TME of clinical specimens. In this article, we review the tumour-promoting non-cell autonomous interactions in the TME and their impact on tumour behaviour. We additionally survey commonly used image analysis programs and highly-multiplexed spatial imaging technologies, and we discuss their relative advantages and limitations. The spatial organization of the TME varies enormously between patients, and so leveraging these technologies in future studies to further characterize how non-cell autonomous interactions impact tumour behaviour may inform the personalization of cancer treatment.​.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microambiente Tumoral / Neoplasias Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microambiente Tumoral / Neoplasias Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza