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Reduced Incidence of Intravitreal Injection-Related Endophthalmitis With Prefilled Syringes.
Feng, Henry L; Abdelwahab, Shareif; Imam, Nareena; Astafurov, Konstantin; Roth, Daniel B.
Afiliación
  • Feng HL; Illinois Retina Associates, Department of Ophthalmology, Rush University Medical Center, Chicago, IL, USA.
  • Abdelwahab S; NJ Retina, Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Imam N; NJ Retina, Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Astafurov K; NJ Retina, Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
  • Roth DB; NJ Retina, Department of Ophthalmology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
J Vitreoretin Dis ; 7(4): 305-309, 2023.
Article en En | MEDLINE | ID: mdl-37927312
Purpose: To evaluate the incidence and clinical characteristics of intravitreal injection-related endophthalmitis cases with antivascular endothelial growth factor (anti-VEGF) medications manufactured as prefilled syringes or non-prefilled preparations. Methods: This retrospective chart review comprised eyes that received intravitreal anti-VEGF at a single-specialty retina practice from January 1, 2014, to December 31, 2019. Eyes diagnosed with injection-related endophthalmitis were identified. Demographic and clinical data were abstracted from medical records, including the type of anti-VEGF agent, baseline and follow-up corrected visual acuity (VA), and microbiologic findings. Results: The review identified 88 cases of intravitreal anti-VEGF injection-related endophthalmitis and 325 990 total injections. Total injections included 32 045 (9.8%) bevacizumab (BEV), 93 073 (28.6%) ranibizumab (RAN), 122 947 (37.7%) aflibercept (AFL), and 77 925 (23.9%) ranibizumab prefilled syringe (RANPFS). Ten of the endophthalmitis cases were related to BEV, 21 to RAN, 45 to AFL, and 12 to RANPFS. The endophthalmitis rate was lowest for RANPFS (0.0154%) (BEV, 0.0312%; RAN, 0.0226%; AFL, 0.0366%) (P = .030). Thirty-four (41.5%) of 82 samples were culture positive. RANPFS had a significantly lower rate of culture-proven postinjection endophthalmitis than the other agents (P = .003). The mean VA for endophthalmitis cases related to RANPFS vs non-prefilled agents was similar at presentation (Snellen 20/2092 vs 20/2327) and at the 3-month follow-up (Snellen 20/201 vs 20/272) (both P > .05). Conclusions: Anti-VEGF medications in prefilled syringes may reduce the risk for medication contamination during injection preparation. RANPFS was associated with a lower rate of injection-related endophthalmitis than non-prefilled anti-VEGF medications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vitreoretin Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Vitreoretin Dis Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos