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Perinatal exposure to bisphenol A impairs cognitive function via the gamma-aminobutyric acid signaling pathway in male rat offspring.
Guo, Yi; Kang, Yuxin; Bai, Wenjie; Liu, Qiling; Zhang, Rongqiang; Wang, Yuxin; Wang, Chong.
Afiliación
  • Guo Y; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Kang Y; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Bai W; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Liu Q; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Zhang R; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Wang Y; College of Health Public, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
  • Wang C; Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
Environ Toxicol ; 39(3): 1235-1244, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37926988
Bisphenol A (BPA) is a common synthetic endocrine disruptor that can be utilized in the fabrication of materials such as polycarbonates and epoxy resins. Numerous studies have linked BPA to learning and memory problems, although the precise mechanism remains unknown. Gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the vertebrate central nervous system, and it is intimately related to learning and memory. This study aims to evaluate whether altered cognitive behavior involves the GABA signaling pathway in male offspring of rats exposed to BPA during the prenatal and early postnatal periods. Pregnant rats were orally given BPA (0, 0.04, 0.4, and 4 mg/kg body weight (BW)/day) from the first day of pregnancy to the 21st day of breastfeeding. Three-week-old male rat offspring were selected for an open-field experiment and a new object recognition experiment to evaluate the effect of BPA exposure on cognitive behavior. Furthermore, the role of GABA signaling markers in the cognition affected by BPA was investigated at the molecular level using western blotting and real-time polymerase chain reaction (RT-PCR). The research demonstrated that BPA exposure impacted the behavior and memory of male rat offspring and elevated the expression of glutamic acid decarboxylase 67 (GAD67), GABA type A receptors subunit (GABAARα1), and GABA vesicle transporter (VGAT) in the hippocampus while decreasing the expression levels of GABA transaminase (GABA-T) and GABA transporter 1 (GAT-1). These findings indicate that the alteration in the expression of GABA signaling molecules may be one of the molecular mechanisms by which perinatal exposure to BPA leads to decreased learning and memory in male rat offspring.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Efectos Tardíos de la Exposición Prenatal Límite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Efectos Tardíos de la Exposición Prenatal Límite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos