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Exogenous neuritin restores auditory following cochlear spiral ganglion neuron denervation of gerbils.
Fei, Gui; Dandan, Song; Haiyan, Wang; Shuai, Zhang; Xiaopin, Sun; Yu, Hong; Yi, Yang; Rong, Chen; Jin, Huang; Xiaoming, Song; Lei, Yang.
Afiliación
  • Fei G; College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, PR China. Electronic address: 565170629@qq.com.
  • Dandan S; College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, PR China; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Haiyan W; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Shuai Z; College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, PR China.
  • Xiaopin S; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Yu H; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Yi Y; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Rong C; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
  • Jin H; College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, PR China. Electronic address: huangjin623@163.com.
  • Xiaoming S; Department of Preventive Medicine, School of Public Health, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China. Electronic address: xmsong@hznu.edu.cn.
  • Lei Y; College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, PR China. Electronic address: 20080009@hznu.edu.cn.
Neurosci Res ; 200: 8-19, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37926219
Spiral ganglion neurons (SGNs) transmit sound signals received by hair cells to the auditory center to produce hearing. The quantity and function are important for maintaining normal hearing function. Limited by the regenerative capacity, SGNs are unable to regenerate spontaneously after injury. Various neurotrophic factors play an important role in the regeneration process. Neuritin is a neurite growth factor that plays an important role in neural plasticity and nerve injury repair. In this study, we used bioinformatics analysis to show that neuritin was negatively correlated with cochlear damage. Then, we aimed to establish a cochlear spiral ganglion-specific sensorineural deafness model in gerbils using ouabain and determine the effects of exogenous neuritin protein in protecting damaged cochlear SGNs and repairing damaged auditory nerve function. The provides a new research strategy and scientific basis for the prevention and treatment of sensorineural deafness caused by the loss of SGNs. We were discovered that neuritin is expressed throughout the development of the gerbil cochlea, primarily in the SGNs and Corti regions. The expression of neuritin was negatively correlated with the sensorineural deafness induced by ouabain. In vitro and in vivo revealed that neuritin significantly maintained the number and arrangement of SGNs and nerve fibers in the damaged cochlea and effectively protected the high-frequency listening function of gerbils.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sordera / Pérdida Auditiva Sensorineural Límite: Animals Idioma: En Revista: Neurosci Res Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sordera / Pérdida Auditiva Sensorineural Límite: Animals Idioma: En Revista: Neurosci Res Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda