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Pancreas patch grafting to treat type 1 diabetes.
Yi, Xianwen; Xie, Youmei; Gerber, David A.
Afiliación
  • Yi X; Department of Surgery, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address: xyi2000@med.unc.edu.
  • Xie Y; Department of Surgery, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address: xiey@neurology.unc.edu.
  • Gerber DA; Department of Surgery, University of North Carolina, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address: david_gerber@med.unc.edu.
Biochem Biophys Res Commun ; 686: 149200, 2023 12 17.
Article en En | MEDLINE | ID: mdl-37926045
Stem/progenitor cell therapy is a promising treatment option for patients with type 1 diabetes (T1D) a disease characterized by autoimmune destruction of pancreatic ß cells. Actively injecting cells into an organ is one option for cell delivery, but in the pancreas, this contributes to acute inflammation and pancreatitis. We employed a patch grafting approach to transplant biliary tree stem cells/progenitor cells (BTSC) onto the surface of the pancreas in diabetic mice. The cells engraft and differentiate into ß-like cells reversing hyperglycemia during a four-month period of observation. In addition, C-peptide and insulin gradually increase in blood circulation without detectable adverse effects during this period. Moreover, the patch graft transplant promoted the proliferation and differentiation of pancreatic ß-like cells with co-expression of the ß cell biomarker. CONCLUSION: BTSC transplantation can effectively attenuate T1D over a four-month period that is vital important for clinical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos