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Comparison of the prognostic impact of IPI and PIT in peripheral T-cell lymphoma in real-world practice with a large elderly population.
Nakamura, Nobuhiko; Kanemura, Nobuhiro; Matsumoto, Takuro; Nakamura, Hiroshi; Ikoma, Yoshikazu; Shibata, Yuhei; Kitagawa, Junnichi; Kasahara, Senji; Yamada, Toshiki; Sawada, Michio; Kaneda, Yuto; Fukuno, Kenji; Takada, Eri; Goto, Hideko; Lee, Shin; Fujita, Kei; Morishita, Tetsuji; Hara, Takeshi; Tsurumi, Hisashi; Shimizu, Masahito.
Afiliación
  • Nakamura N; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan. nakamura.nobuhiko.s1@f.gifu-u.ac.jp.
  • Kanemura N; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
  • Matsumoto T; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
  • Nakamura H; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
  • Ikoma Y; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
  • Shibata Y; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan.
  • Kitagawa J; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan.
  • Kasahara S; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan.
  • Yamada T; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan.
  • Sawada M; Department of Hematology, Gifu Prefectural General Medical Center, Gifu, Japan.
  • Kaneda Y; Department of Hematology, Gifu Red Cross Hospital, Gifu, Japan.
  • Fukuno K; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.
  • Takada E; Department of Hematology, Takayama Red Cross Hospital, Takayama, Japan.
  • Goto H; Department of Hematology, Takayama Red Cross Hospital, Takayama, Japan.
  • Lee S; Department of Hematology, Gihoku Kosei Hospital, Yamagata, Japan.
  • Fujita K; Department of Hematology, Chuno Kosei Hospital, Seki, Japan.
  • Morishita T; Department of Hematology, Matsunami General Hospital, Gifu, Japan.
  • Hara T; Department of Hematology, Matsunami General Hospital, Gifu, Japan.
  • Tsurumi H; Department of Hematology, Matsunami General Hospital, Gifu, Japan.
  • Shimizu M; Department of Hematology, Matsunami General Hospital, Gifu, Japan.
Sci Rep ; 13(1): 19060, 2023 11 04.
Article en En | MEDLINE | ID: mdl-37925551
We compared the predictive ability of the International Prognostic Index (IPI), a frequently used prognostic model for peripheral T-cell lymphoma (PTCL), with that of a type-specific prognostic model, the Prognostic Index for PTCL-U (PIT). We retrospectively analyzed 113 patients diagnosed with PTCL. The median age was 67 years (range, 16-88 years), 75 patients (66%) were male, and the most common disease type was PTCL, not otherwise specified (69%). With a median follow-up of 6.8 years (interquartile range, 2.7-9.9 years), 5-year survival rates for the four groups in IPI were 85%, 62%, 49%, and 13%, respectively. Similarly, 5-year survival rates for the four groups in PIT were 83%, 64%, 49%, and 19%, respectively. The area under the receiving operating characteristic curve for predicting mortality from PIT (0.725) was not significantly different from that from the IPI (0.685, P = 0.134). Multivariable analysis showed that performance status ≥ 2 (P < 0.0001) and extranodal lesions ≥ 2 (P = 0.029) were significantly associated with lower overall survival. The present study found no significant difference in prognostic ability between the IPI and PIT for PTCL, and both models appear useful as predictive models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico Límite: Aged / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico Límite: Aged / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido