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Sex Differences in the Clinical Outcomes of Patients With Takotsubo Stress Cardiomyopathy: A Meta-Analysis of Observational Studies.
Abusnina, Waiel; Elhouderi, Eiman; Walters, Ryan W; Al-Abdouh, Ahmad; Mostafa, Mostafa R; Liu, John L; Mazozy, Ruqayah; Mhanna, Mohammed; Ben-Dor, Itsik; Dufani, Jalal; Kabach, Amjad; Michos, Erin D; Aboeata, Ahemd; Mamas, Mamas A.
Afiliación
  • Abusnina W; Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE, USA; Section of Interventional Cardiology, Medstar Washington Hospital Center, Washington DC. Electronic address: dr.abusnina@gmail.com.
  • Elhouderi E; Department of Medicine, Beaumont Hospital, Dearborn, MI, USA.
  • Walters RW; Department of Clinical Research and Public Health, Creighton University School of Medicine, Omaha, NE, USA.
  • Al-Abdouh A; Division of Hospital Medicine, University of Kentucky, Lexington, KY, USA.
  • Mostafa MR; Department of Medicine, Rochester Regional Health/Unity Hospital, Rochester, New York, USA.
  • Liu JL; Creighton University School of Medicine, Omaha, NE, USA.
  • Mazozy R; Department of Cardiology, Zliten Medical Center, Zliten, Libya.
  • Mhanna M; Division of Cardiology, Department of Medicine, University of Iowa, IA, USA.
  • Ben-Dor I; Section of Interventional Cardiology, Medstar Washington Hospital Center, Washington DC.
  • Dufani J; Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE, USA.
  • Kabach A; Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE, USA.
  • Michos ED; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Aboeata A; Division of Cardiovascular Diseases, Creighton University School of Medicine, Omaha, NE, USA.
  • Mamas MA; Keele CV Research Group, Keele University, UK.
Am J Cardiol ; 211: 316-325, 2024 Jan 15.
Article en En | MEDLINE | ID: mdl-37923154
The incidence of takotsubo stress cardiomyopathy (TSCM) in males is low compared with females. Gender-based differences in clinical outcomes of TSCM are not well characterized. The aim of this meta-analysis was to analyze whether gender-based differences are observed in TSCM clinical outcomes. A comprehensive literature search of PubMed, Embase, Cochrane Library database, and Web of Science was performed from inception to June 20, 2022, for studies comparing the clinical outcomes between male and female patients with TSCM. The primary outcome of interest was in-hospital all-cause mortality and cardiogenic shock. The secondary outcomes were cardiovascular mortality, receipt of mechanical ventilation, intra-aortic balloon pump, occurrence of ventricular arrhythmia, and left ventricular thrombus. A random-effects model was used to calculate the risk ratios (RR) and confidence intervals (CI). Heterogenicity was assessed using the Higgins I2 index. Twelve observational studies involving 51,213 patients (4,869 males and 46,344 females) were included in the meta-analysis. Male gender was associated with statistically significant higher in-hospital all-cause mortality compared with females in patients with TSCM (RR 2.17, 95% CI 1.77 to 2.67, p <0.001). The rate of cardiogenic shock was significantly higher in males with TSCM compared with females (RR 1.66, 95% CI 1.29 to 2.12, p <0.001). Our meta-analysis showed a difference in the clinical outcomes of TSCM between men and women. Male gender was associated with a two-fold greater in-hospital all-cause mortality risk compared with female gender. The higher mortality risk associated with male gender deserves further study, particularly whether it represents later recognition of the condition and disparities in treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Cardiogénico / Cardiomiopatía de Takotsubo Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Am J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Cardiogénico / Cardiomiopatía de Takotsubo Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Am J Cardiol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos