4-methoxycinnamyl p-coumarate reduces neuroinflammation by blocking NF-&#954;B, MAPK, and Akt/GSK-3ß pathways and enhancing Nrf2/HO-1 signaling cascade in microglial cells.

Poonasri, Mayuree; Mankhong, Sakulrat; Chiranthanut, Natthakarn; Srisook, Klaokwan

4-methoxycinnamyl p-coumarate reduces neuroinflammation by blocking NF-κB, MAPK, and Akt/GSK-3ß pathways and enhancing Nrf2/HO-1 signaling cascade in microglial cells.

Poonasri, Mayuree; Mankhong, Sakulrat; Chiranthanut, Natthakarn; Srisook, Klaokwan.

Afiliación

Poonasri M; Department of Biochemistry and Research Unit of Natural Bioactive Compounds for Healthcare Products Development, Faculty of Science, Burapha University, Chonburi 20131, Thailand; Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi, Thailand.
Mankhong S; Department of Development and Stem Cells, Institute of Genetics and Molecular and Cellular Biology (IGBMC), 1 Rue Laurent Fries, 67404 Illkirch, France.
Chiranthanut N; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Srisook K; Department of Biochemistry and Research Unit of Natural Bioactive Compounds for Healthcare Products Development, Faculty of Science, Burapha University, Chonburi 20131, Thailand; Center of Excellence for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi, Thailand. Electronic

Biomed Pharmacother ; 168: 115808, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37922650

Asunto(s)

FN-kappa B; Proteínas Proto-Oncogénicas c-akt; Humanos; FN-kappa B/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Microglía; Proteínas Quinasas Activadas por Mitógenos/metabolismo; Enfermedades Neuroinflamatorias; Hemo-Oxigenasa 1/metabolismo; Lipopolisacáridos/farmacología; Lipopolisacáridos/metabolismo; Antiinflamatorios/farmacología; Antiinflamatorios/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintasa de Tipo II/metabolismo

Palabras clave

4-methoxycinnamyl p-coumarate; Anti-neuroinflammatory activity; Heme oxygenase-1; Microglial cell; Nitric oxide; Prostaglandins E2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Proteínas Proto-Oncogénicas c-akt Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Francia

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