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Needle-free electronically controlled jet injection with corticosteroids in recalcitrant keloid scars: a retrospective study and patient survey.
Bik, Liora; Elmzoon, Ixora; Wolkerstorfer, Albert; Prens, Errol P; van Doorn, Martijn B A.
Afiliación
  • Bik L; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands. bik.liora@gmail.com.
  • Elmzoon I; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
  • Wolkerstorfer A; Department of Dermatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Prens EP; Department of Dermatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • van Doorn MBA; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Lasers Med Sci ; 38(1): 250, 2023 Nov 02.
Article en En | MEDLINE | ID: mdl-37917309
First-line treatment of keloids consists of intralesional needle injections with corticosteroids, but generally entails multiple painful sessions, resulting in variable clinical outcomes. Novel needle-free jet injectors may facilitate more effective and patient-friendly dermal drug delivery. Here, we evaluated the effectiveness, tolerability and patient satisfaction of intralesional triamcinolone-acetonide (TCA) treatment in recalcitrant keloids using an electronically controlled pneumatic injector (EPI). A retrospective study was conducted in recalcitrant keloid patients with a history of severe pain during needle injections who received three sessions of EPI + TCA. Outcome measures included Patient and Observer Scar Assessment Scale (POSAS), Global Aesthetic Improvement Scale (GAIS), treatment-related pain (NRS), adverse effects, and patient satisfaction (survey). Ten patients with in total 283 keloids were included. The POSAS score significantly improved at follow-up and GAIS was reported as '(very) improved' for all patients. EPI + TCA was well-tolerated with a significantly lower NRS pain score compared to needle + TCA (pilot treatment). Only minor adverse effects occurred, and 90% of patients preferred EPI over needle treatment. EPI + TCA is an effective and tolerable treatment for patients with recalcitrant keloids. The minimal treatment-related pain and high patient satisfaction makes it a promising treatment for patients with needle-phobia and/or severe pain during needle injections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatriz Hipertrófica / Queloide Límite: Humans Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatriz Hipertrófica / Queloide Límite: Humans Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido