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Low cholesterol levels are associated with increasing risk of plasma cell neoplasm: A UK biobank cohort study.
Li, Linfeng; Yu, Zhengyu; Ren, Jianjun; Niu, Ting.
Afiliación
  • Li L; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Yu Z; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
  • Ren J; Department of Otolaryngology-Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.
  • Niu T; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, China.
Cancer Med ; 12(22): 20964-20975, 2023 11.
Article en En | MEDLINE | ID: mdl-37908181
BACKGROUND: Plasma cell neoplasms are a group of hematologic neoplasms that often develop in the elderly population. The relationship between cholesterol levels and hematologic malignancy has been identified in population studies. However, it is still unclear if there is a relationship between cholesterol levels and plasma cell neoplasm in European ancestry. METHODS: Prospective cohorts included 502,507 individuals from the UK Biobank who were followed up to 2019 and assessed total cholesterol(TC) levels, low-density lipoprotein (LDL) levels, high-density lipoprotein (HDL) levels, apolipoprotein A (ApoA) and apolipoprotein B (ApoB) as risk factors for plasma cell neoplasms with Cox proportional hazard regression and restricted cubic spline model. We also used two-sample Mendelian randomization to determine if the cholesterol level has a causal effect on developing plasma cell neoplasms. RESULTS: We observed 1819 plasma cell neoplasm cases during 14.2 years of follow-up in the UK Biobank. We found higher blood serum cholesterol levels at baseline were associated with a lower risk of plasma cell neoplasm in our study. All lipid profiles we analyzed in this study were inversely associated with plasma cell neoplasm risk (all ptrend <0.005) but triglycerides did not have such association. However, there was no suggestive association of genetically predicted serum LDL, HDL, and total cholesterol levels with multiple myeloma. CONCLUSION: Low serum total cholesterol, LDL, HDL, ApoA, and ApoB levels were all associated with increasing the risk of plasma cell neoplasm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple Límite: Aged / Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple Límite: Aged / Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos