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First-in-human phase I/Ib study of NIZ985, a recombinant heterodimer of IL-15 and IL-15Rα, as a single agent and in combination with spartalizumab in patients with advanced and metastatic solid tumors.
Leidner, Rom; Conlon, Kevin; McNeel, Douglas G; Wang-Gillam, Andrea; Gupta, Sumati; Wesolowski, Robert; Chaudhari, Monica; Hassounah, Nadia; Lee, Jong Bong; Ho Lee, Lang; O'Keeffe, Jessica A; Lewis, Nancy; Pavlakis, George N; Thompson, John A.
Afiliación
  • Leidner R; EACRI, Providence Cancer Institute, Portland, Oregon, USA.
  • Conlon K; National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • McNeel DG; Department of Medicine, Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin, USA.
  • Wang-Gillam A; Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Gupta S; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
  • Wesolowski R; Division of Medical Oncology, James Cancer Hospital and the Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
  • Chaudhari M; Decision Sciences (DSSM), IQVIA, Durham, North Carolina, USA.
  • Hassounah N; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Lee JB; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
  • Ho Lee L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • O'Keeffe JA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Lewis N; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA.
  • Pavlakis GN; Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
  • Thompson JA; SCCA, University of Washington, Seattle, Washington, USA jat@uw.edu.
J Immunother Cancer ; 11(10)2023 10.
Article en En | MEDLINE | ID: mdl-37907221
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Primarias Secundarias / Melanoma / Antineoplásicos Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Primarias Secundarias / Melanoma / Antineoplásicos Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido