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Comparative efficacy of vancomycin in treating ST5 and ST764 methicillin-resistant Staphylococcus aureus infections in adult patients.
Fan, Yaxin; Zhang, Kaiting; Chen, Mengting; Li, Nanyang; Liu, Xiaofen; Yang, Minjie; Liang, Xiaoyu; Wu, Jufang; Guo, Beining; Zheng, Huajun; Zhu, Yongqiang; Zhang, Fengying; Hang, Jingqing; Zhang, Huifang; Wang, Ruilan; Yuan, Qing; Song, Xiaolian; Wu, Shengbin; Shen, Bo; Zhang, Jing.
Afiliación
  • Fan Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang K; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Chen M; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Li N; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Liu X; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Yang M; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Liang X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Wu J; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Guo B; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Zheng H; Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhu Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang F; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Hang J; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang H; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Wang R; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Yuan Q; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Song X; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Wu S; Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai, China.
  • Shen B; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
  • Zhang J; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
mSphere ; 8(6): e0045723, 2023 Dec 20.
Article en En | MEDLINE | ID: mdl-37905831
IMPORTANCE: Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to multiple drugs and can cause serious infections. In recent years, one of the most widespread strains of MRSA worldwide has been the clonal complex 5 (CC5) type. Sequence type 5 (ST5) and ST764 are two prevalent CC5 strains. Although ST5 and ST764 are genotypically identical, ST764 is classified as a hybrid variant of ST5 with characteristics of community-associated MRSA (CA-MRSA). In contrast to ST5, ST764 lacks the tst and sec genes but carries the staphylococcal enterotoxin B (seb) gene. Vancomycin is commonly used as the first-line treatment for MRSA infections. However, it is currently unclear whether the genetic differences between the ST5 and ST764 strains have any impact on the efficacy of vancomycin in treating MRSA infections. We conducted a prospective observational study comparing the efficacy of vancomycin against ST5-MRSA and ST764-MRSA in five hospitals in China. There were significant differences in bacteriological efficacy between the two groups, with virulence genes, such as the tst gene, being a risk factor for bacterial persistence (adjusted odds ratio, 4.509; 95% confidence interval, 1.216 to 16.724; P = 0.024). In the future, it may be necessary to consider personalized vancomycin treatment strategies based on the genetic characteristics of MRSA isolates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Límite: Adult / Humans Idioma: En Revista: MSphere Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus Resistente a Meticilina Límite: Adult / Humans Idioma: En Revista: MSphere Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos