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Thiamet G as a Potential Treatment for Polycystic Kidney Disease.
Su, Wen-Cheng; Hung, Chi-Feng; Wang, Yi-Chieh; Peng, Hubert; Huang, Wen-Hung; Lo, Yi-Lun; Lo, Yun-Hwa; Chen, Yi-Cheng; Su, Hsin-Hui; Chen, Yung-Liang.
Afiliación
  • Su WC; Department of Medical Laboratory Science and Biotechnology, Yuan Pei University of Medical Technology, Hsinchu, Taiwan, R.O.C.
  • Hung CF; Department of Urology, Ditmanson Medical Foundation Chia-yi Christian Hospital, Chia-Yi City, Taiwan, R.O.C.
  • Wang YC; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.
  • Peng H; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, R.O.C.
  • Huang WH; Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
  • Lo YL; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  • Lo YH; Department of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan, R.O.C.
  • Chen YC; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.
  • Su HH; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, R.O.C. hsinhuisu@gm.cnu.edu.tw.
  • Chen YL; Department of Medical Laboratory Science and Biotechnology, Yuan Pei University of Medical Technology, Hsinchu, Taiwan, R.O.C.; yuangliang@mail.ypu.edu.tw.
In Vivo ; 37(6): 2524-2532, 2023.
Article en En | MEDLINE | ID: mdl-37905652
BACKGROUND/AIM: Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder primarily caused by mutations in Pkd1 (PC1), which account for the majority of ADPKD cases. These mutations contribute to the formation of cysts in the kidneys and other organs, ultimately leading to renal failure. Unfortunately, there are currently no available preventive treatments for this disease. MATERIALS AND METHODS: In this study, we utilized Pkd1-knockdown mice and cells to investigate the potential involvement of O-GlcNAcylation in the progression of PKD. Additionally, we examined the effects of thiamet G, an inhibitor of O-GlcNAcase (OGA), on PKD mice. RESULTS: Our findings indicate that both O-GlcNAcylation and OGT (O-GlcNAc transferase) were downregulated in the renal tissues of Pkd1-silenced mice. Furthermore, O-GlcNAcylation was shown to regulate the stability and function of the C-terminal cytoplasmic tail (CTT) of PC1. Treatment of PKD mice with thiamet G resulted in a reduction of renal cytogenesis in these animals. CONCLUSION: These results highlight the unique role of O-GlcNAcylation in the development of cyst formation in PKD and propose it as a potential therapeutic target for the treatment of PKD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón Poliquístico Autosómico Dominante / Enfermedades Renales Poliquísticas Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón Poliquístico Autosómico Dominante / Enfermedades Renales Poliquísticas Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Grecia