DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction.

Chandrashekar, Pramod Bharadwaj; Alatkar, Sayali; Wang, Jiebiao; Hoffman, Gabriel E; He, Chenfeng; Jin, Ting; Khullar, Saniya; Bendl, Jaroslav; Fullard, John F; Roussos, Panos; Wang, Daifeng

Chandrashekar, Pramod Bharadwaj; Alatkar, Sayali; Wang, Jiebiao; Hoffman, Gabriel E; He, Chenfeng; Jin, Ting; Khullar, Saniya; Bendl, Jaroslav; Fullard, John F; Roussos, Panos; Wang, Daifeng.

Afiliación

Chandrashekar PB; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Alatkar S; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53076, USA.
Wang J; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Hoffman GE; Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, 53076, USA.
He C; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Jin T; Center for Disease Neurogenomics, Department of Psychiatry and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Khullar S; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Bendl J; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53076, USA.
Fullard JF; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Roussos P; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53076, USA.
Wang D; Waisman Center, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Genome Med ; 15(1): 88, 2023 10 31.

Article en En | MEDLINE | ID: mdl-37904203

Asunto(s)

Enfermedad de Alzheimer; Aprendizaje Automático; Animales; Ratones; Redes Neurales de la Computación; Genotipo; Fenotipo; Enfermedad de Alzheimer/genética

Palabras clave

Alzheimer's disease; Auxiliary learning; Cell-type gene regulatory networks; Cross-modality imputation; Deep learning; Genotypephenotype prediction; Prioritizing disease risk variants; Schizophrenia

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Aprendizaje Automático Límite: Animals Idioma: En Revista: Genome Med Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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