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Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney.
ALRashdi, Barakat M; Mohamed, Roaya A; Mohamed, Amal H; Samoul, Feryal A; Mohamed, Mazen I; Moussa, Mohsen M; Alrashidi, Saad M; Dawod, Bassel; Habotta, Ola A; Abdel Moneim, Ahmed E; Ramadan, Shimaa S.
Afiliación
  • ALRashdi BM; Department of Biology, College of Science, Jouf University, Sakaka 72388, Saudi Arabia.
  • Mohamed RA; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
  • Mohamed AH; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
  • Samoul FA; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
  • Mohamed MI; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
  • Moussa MM; Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
  • Alrashidi SM; Consultant Radiation Oncology, Comprehensive Cancer Centre, King Fahad Medical City and College of medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Dawod B; McMaster Children's Hospital, Faculty of Health Sciences, Hamilton, Ontario, Canada.
  • Habotta OA; Department of Biology, College of Science, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
  • Abdel Moneim AE; Department of Zoology, Faculty of Science, Fayoum University, Fayoum, Egypt.
  • Ramadan SS; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Biosci Rep ; 43(11)2023 11 30.
Article en En | MEDLINE | ID: mdl-37902021
Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with selenium nanoparticles (Tur-SeNPs) against CDDP-mediated renal impairment in mice and the mechanisms underlying this effect. Mice were orally treated with Tur extract (200 mg/kg) or Tur-SeNPs (0.5 mg/kg) for 7 days after administration of a single dose of CDDP (5 mg/kg, i.p.). N-acetyl cysteine NAC (100 mg/kg) was used as a standard antioxidant compound. The results revealed that Tur-SeNPs counteracted CDDP-mediated serious renal effects in treated mice. Compared with the controls, Tur or Tur-SeNPs therapy remarkably decreased the kidney index along with the serum levels of urea, creatinine, Kim-1, and NGAL of the CDDP-injected mice. Furthermore, Tur-SeNPs ameliorated the renal oxidant status of CDDP group demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Tur-SeNPs treatment also restored the renal histological features attained by CDDP challenge and hindered renal apoptosis through decreasing the Bax levels and increasing Bcl-2 levels. Altogether, these outcomes suggest that the administration of Tur conjugated with SeNPs is effective neoadjuvant chemotherapy to guard against the renal adverse effects that are associated with CDDP therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Cisplatino Límite: Animals Idioma: En Revista: Biosci Rep Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selenio / Cisplatino Límite: Animals Idioma: En Revista: Biosci Rep Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido