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Predictive Value of Recurrence of Solid and Micropapillary Subtypes in Lung Adenocarcinoma.
Motono, Nozomu; Mizoguchi, Takaki; Ishikawa, Masahito; Iwai, Shun; Iijima, Yoshihito; Uramoto, Hidetaka.
Afiliación
  • Motono N; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
  • Mizoguchi T; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
  • Ishikawa M; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
  • Iwai S; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
  • Iijima Y; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
  • Uramoto H; Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Japan.
Oncology ; 102(4): 366-373, 2024.
Article en En | MEDLINE | ID: mdl-37899040
INTRODUCTION: Although histological subtype in lung adenocarcinoma has been reported as a poor prognostic factor in several studies, its utility has not yet been revealed as an adaptation criterion of postoperative adjuvant chemotherapy. METHODS: Four hundred ninety-four lung adenocarcinoma patients were enrolled in this retrospective study. A subanalysis was performed in 420 lung adenocarcinoma patients with pathological stage 0-I disease for risk factors of postoperative recurrence. RESULTS: Maximum standardized uptake value (SUVmax) (p < 0.01), pathological stage ≥II (p < 0.04), and adjuvant chemotherapy (p < 0.01) were risk factors for recurrence in the multivariate analysis, whereas histological subtype was not a significant factor for recurrence at all stages. In the subanalysis, univariate analysis showed that carcinoembryonic antigen expression (p < 0.01), prognostic nutrition index (p = 0.03), SUVmax (p < 0.01), lymphatic invasion (p < 0.01), vascular invasion (p < 0.01), grade 3-4 differentiation (p < 0.01), pathological stage ≥IA3 (p < 0.01), and histological subtype (p = 0.03) were significant risk factors of recurrence. SUVmax (p < 0.01) was the only risk factor for recurrence in the multivariate analysis, whereas histological subtype was not (p = 0.07). Relapse-free survival (RFS) was significantly worse in the micropapillary- and solid-predominant subtype groups than in the other subtypes (p = 0.01). On the other hand, RFS with or without uracil-tegafur as adjuvant chemotherapy in lung micropapillary- or solid-predominant adenocarcinoma patients with pathological stage IA-IB disease was not significantly different. CONCLUSION: This study suggested that histological subtypes, such as micropapillary- or solid-predominant pattern, are risk factors for recurrence in pathological stage 0-I lung adenocarcinoma and may be necessary adjuvant chemotherapy instead of uracil-tegafur.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma del Pulmón / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Oncology Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma del Pulmón / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Oncology Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza