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Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex.
Wu, Jun Yao; Cho, Su-Ji; Descant, Katherine; Li, Peter H; Shapson-Coe, Alexander; Januszewski, Michal; Berger, Daniel R; Meyer, Cailyn; Casingal, Cristine; Huda, Ariba; Liu, Jiaqi; Ghashghaei, Tina; Brenman, Mikayla; Jiang, Michelle; Scarborough, Joseph; Pope, Art; Jain, Viren; Stein, Jason L; Guo, Jiami; Yasuda, Ryohei; Lichtman, Jeff W; Anton, E S.
Afiliación
  • Wu JY; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Cho SJ; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Descant K; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Li PH; Google Research, Mountain View, CA 94043, USA.
  • Shapson-Coe A; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Januszewski M; Google Research, Mountain View, CA 94043, USA.
  • Berger DR; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Meyer C; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Casingal C; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Huda A; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Liu J; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Ghashghaei T; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Brenman M; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Jiang M; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Scarborough J; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Pope A; Google Research, Mountain View, CA 94043, USA.
  • Jain V; Google Research, Mountain View, CA 94043, USA.
  • Stein JL; UNC Neuroscience Center and the Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Guo J; Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
  • Yasuda R; Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA. Electronic address: ryohei.yasuda@mpfi.org.
  • Lichtman JW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: jeff@mcb.harvard.edu.
  • Anton ES; UNC Neuroscience Center and the Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: anton@med.unc.edu.
Neuron ; 112(1): 41-55.e3, 2024 Jan 03.
Article en En | MEDLINE | ID: mdl-37898123
Primary cilia act as antenna receivers of environmental signals and enable effective neuronal or glial responses. Disruption of their function is associated with circuit disorders. To understand the signals these cilia receive, we comprehensively mapped cilia's contacts within the human cortical connectome using serial-section EM reconstruction of a 1 mm3 cortical volume, spanning the entire cortical thickness. We mapped the "contactome" of cilia emerging from neurons and astrocytes in every cortical layer. Depending on the layer and cell type, cilia make distinct patterns of contact. Primary cilia display cell-type- and layer-specific variations in size, shape, and microtubule axoneme core, which may affect their signaling competencies. Neuronal cilia are intrinsic components of a subset of cortical synapses and thus a part of the connectome. This diversity in the structure, contactome, and connectome of primary cilia endows each neuron or glial cell with a unique barcode of access to the surrounding neural circuitry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cilios / Conectoma Límite: Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cilios / Conectoma Límite: Humans Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos