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'I am afraid you will see the stain on my soul': Direct gaze neural processing in individuals with PTSD after moral injury recall.
Andrews, Krysta; Lloyd, Chantelle S; Densmore, Maria; Kearney, Breanne E; Harricharan, Sherain; McKinnon, Margaret C; Théberge, Jean; Jetly, Rakesh; Lanius, Ruth A.
Afiliación
  • Andrews K; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.
  • Lloyd CS; Homewood Research Institute, Guelph, ON N1E 6K9, Canada.
  • Densmore M; Homewood Research Institute, Guelph, ON N1E 6K9, Canada.
  • Kearney BE; Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
  • Harricharan S; Department of Psychology, Neuroscience, and Behaviour, McMaster University, Hamilton, ON L8S 4K1, Canada.
  • McKinnon MC; Department of Psychiatry, Western University, London, ON N6C 0A7, Canada.
  • Théberge J; Imaging Division, Lawson Health Research Institute, London, ON N6A 4V2, Canada.
  • Jetly R; Department of Neuroscience, Western University, London, ON N6A 3K7, Canada.
  • Lanius RA; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON L8N 3K7, Canada.
Soc Cogn Affect Neurosci ; 18(1)2023 10 26.
Article en En | MEDLINE | ID: mdl-37897804
Direct eye contact is essential to understanding others' thoughts and feelings in social interactions. However, those with post-traumatic stress disorder (PTSD) and exposure to moral injury (MI) may exhibit altered theory-of-mind (ToM)/mentalizing processes and experience shame which precludes one's capacity for direct eye contact. We investigated blood oxygenation level-dependent (BOLD) responses associated with direct vs averted gaze using a virtual reality paradigm in individuals with PTSD (n = 28) relative to healthy controls (n = 18) following recall of a MI vs a neutral memory. Associations between BOLD responses and clinical symptomatology were also assessed. After MI recall, individuals with PTSD showed greater activation in the right temporoparietal junction as compared to controls (T = 4.83; pFDR < 0.001; k = 237) during direct gaze. No significant activation occurred during direct gaze after neutral memory recall. Further, a significant positive correlation was found between feelings of distress and right medial superior frontal gyrus activation in individuals with PTSD (T = 5.03; pFDR = 0.049; k = 123). These findings suggest that direct gaze after MI recall prompts compensatory ToM/mentalizing processing. Implications for future interventions aimed at mitigating the effects of PTSD on social functioning are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Infarto del Miocardio Límite: Humans Idioma: En Revista: Soc Cogn Affect Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Infarto del Miocardio Límite: Humans Idioma: En Revista: Soc Cogn Affect Neurosci Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido