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Longitudinal investigation of aortic dissection in mice with computational fluid dynamics.
Bäumler, Kathrin; Phillips, Evan H; Grande Gutiérrez, Noelia; Fleischmann, Dominik; Marsden, Alison L; Goergen, Craig J.
Afiliación
  • Bäumler K; Department of Radiology, Stanford University, CA, USA.
  • Phillips EH; Weldon School of Biomedical Engineering, Purdue University, IN, USA.
  • Grande Gutiérrez N; Department of Pharmaceutical Sciences, University of IL at Chicago, IL, USA.
  • Fleischmann D; Department of Mechanical Engineering, Carnegie Mellon University, PA, USA.
  • Marsden AL; Department of Radiology, Stanford University, CA, USA.
  • Goergen CJ; Department of Bioengineering, Stanford University, CA, USA.
Comput Methods Biomech Biomed Engin ; : 1-14, 2023 Oct 28.
Article en En | MEDLINE | ID: mdl-37897230
Predicting late adverse events in aortic dissections is challenging. One commonly observed risk factor is partial thrombosis of the false lumen. In this study we investigated false lumen thrombus progression over 7 days in four mice with angiotensin II-induced aortic dissection. We performed computational fluid dynamic simulations with subject-specific boundary conditions from velocity and pressure measurements. We investigated endothelial cell activation potential, mean velocity, thrombus formation potential, and other hemodynamic factors. Our findings support the hypothesis that flow stagnation is the predominant hemodynamic factor driving a large thrombus ratio in false lumina, particularly those with a single fenestration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Comput Methods Biomech Biomed Engin Asunto de la revista: ENGENHARIA BIOMEDICA / FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Comput Methods Biomech Biomed Engin Asunto de la revista: ENGENHARIA BIOMEDICA / FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido