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Acute and Sub-Chronic Intraperitoneal Toxicity Studies of the Elsholtzia ciliata Herbal Extract in Balb/c Mice.
Macianskiene, Regina; Zigmantaite, Vilma; Andriule, Inga; Pangonyte, Dalia; Sadauskiene, Ilona; Arandarcikaite, Odeta; Stankevicius, Arunas; Grigas, Juozas; Pautienius, Arnoldas; Treinys, Rimantas; Navalinskas, Antanas; Grigaleviciute, Ramune; Kucinskas, Audrius; Pudziuvelyte, Lauryna; Bernatoniene, Jurga; Jurevicius, Jonas.
Afiliación
  • Macianskiene R; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Zigmantaite V; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Andriule I; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Pangonyte D; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Sadauskiene I; Institute of Neuroscience, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Arandarcikaite O; Institute of Neuroscience, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Stankevicius A; Department of Anatomy and Physiology, Veterinary Faculty, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
  • Grigas J; Department of Anatomy and Physiology, Veterinary Faculty, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
  • Pautienius A; Department of Anatomy and Physiology, Veterinary Faculty, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
  • Treinys R; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Navalinskas A; Institute of Cardiology, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Grigaleviciute R; Biological Research Center, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
  • Kucinskas A; Biological Research Center, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
  • Pudziuvelyte L; Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Bernatoniene J; Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
  • Jurevicius J; Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Pharmaceutics ; 15(10)2023 Oct 03.
Article en En | MEDLINE | ID: mdl-37896177
Elsholtzia ciliata essential oil (E. ciliata) has been reported to have an impact on the cardiovascular system. However, its toxicity remains unknown. Therefore, the objective of this investigation was to evaluate the toxicological aspects of the E. ciliata extract. Male Balb/c mice were subjected to either acute (a single dose administered for 24 h) or sub-chronic (daily dose for 60 days) intraperitoneal injections of the E. ciliata extract. The mice were assessed for blood hematological/biochemical profiles, mitochondrial functions, and histopathological changes. Additionally, in vitro cytotoxicity assessments of the E. ciliata extract were performed on immobilized primate kidney cells (MARC-145, Vero) and rat liver cells (WBF344) to evaluate cell viability. The control groups received an equivalent volume of olive oil or saline. Our results demonstrated no significant detrimental effects on hematological and biochemical parameters, mitochondrial functions, cellular cytotoxicity, or pathological alterations in vital organs following the intraperitoneal administration of the E. ciliata extract over the 60-day sub-chronic toxicity study. In general, E. ciliata displayed no indications of toxicity, suggesting that the E. ciliata extract is a safe natural product with a well-defined therapeutic and protective index (found to be 90 and 54, respectively) in Balb/c mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Suiza