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Actin Alpha 2, Smooth Muscle (ACTA2) Is Involved in the Migratory Potential of Malignant Gliomas, and Its Increased Expression at Recurrence Is a Significant Adverse Prognostic Factor.
Hoshimaru, Takumi; Nonoguchi, Naosuke; Kosaka, Takuya; Furuse, Motomasa; Kawabata, Shinji; Yagi, Ryokichi; Kurisu, Yoshitaka; Kashiwagi, Hideki; Kameda, Masahiro; Takami, Toshihiro; Kataoka-Sasaki, Yuko; Sasaki, Masanori; Honmou, Osamu; Hiramatsu, Ryo; Wanibuchi, Masahiko.
Afiliación
  • Hoshimaru T; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Nonoguchi N; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kosaka T; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Furuse M; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kawabata S; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Yagi R; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kurisu Y; Department of Pathology, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kashiwagi H; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kameda M; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Takami T; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Kataoka-Sasaki Y; Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, Japan.
  • Sasaki M; Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, Japan.
  • Honmou O; Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido 060-8556, Japan.
  • Hiramatsu R; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
  • Wanibuchi M; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan.
Brain Sci ; 13(10)2023 Oct 19.
Article en En | MEDLINE | ID: mdl-37891844
Malignant glioma is a highly invasive tumor, and elucidating the glioma invasion mechanism is essential for developing novel therapies. We aimed to highlight actin alpha 2, smooth muscle (ACTA2) as potential biomarkers of brain invasion and distant recurrence in malignant gliomas. Using the human malignant glioma cell line, U251MG, we generated ACTA2 knockdown (KD) cells treated with small interfering RNA, and the cell motility and proliferation of the ACTA2 KD group were analyzed. Furthermore, tumor samples from 12 glioma patients who underwent reoperation at the time of tumor recurrence were utilized to measure ACTA2 expression in the tumors before and after recurrence. Thereafter, we examined how ACTA2 expression correlates with the time to tumor recurrence and the mode of recurrence. The results showed that the ACTA2 KD group demonstrated a decline in the mean motion distance and proliferative capacity compared to the control group. In the clinical glioma samples, ACTA2 expression was remarkably increased in recurrent samples compared to the primary samples from the same patients, and the higher the change in ACTCA2 expression from the start to relapse, the shorter the progression-free survival. In conclusion, ACTA2 may be involved in distant recurrence in clinical gliomas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Sci Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza